A meta-analysis was conducted by searching the Embase, Embase classic and Pubmed databases between 1978 -2021 exploring prevalence pouchitis in UC and FAP. We then performed a random effects model in order to find the pooled prevalence of pouchitis and used odds ratios to report differences in prevalence of pouchitis in UC and FAP.
Fifty-nine full papers and conference abstracts were included in the meta-analysis comprising of 18,117 patients with UC and 860 with FAP. The prevalence of pouchitis in UC was 0.32 (95% CI: 0.27 – 0.37) and in FAP was found to be 0.06 (95% CI: 0.03-0.15). The odds ratio of pouchitis in UC compared with FAP patients was 4.95 (95% CI: 3.17-7.72 p<0.0001).
Our findings support the consensus that the prevalence of pouchitis is higher in UC than in FAP. More significantly our findings suggest that the true prevalence of pouchitis is higher than commonly reported in the literature. This literature may help counsel patients prior to undergoing restorative proctocolectomy.
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