Pharmacogenomic overlap between antidepressant treatment response in major depression & antidepressant associated treatment emergent mania in bipolar disorder.

Feb 19, 2024

Experts: Nicolas A Nuñez, Brandon J Coombes, Lindsay Melhuish Beaupre, Aysegul Ozerdem, Manuel Gardea Resendez, Francisco Romo-Nava, David J Bond, Marin Veldic, Balwinder Singh, Katherine M Moore, Hannah K Betcher, Simon Kung, Miguel L Prieto, Manuel Fuentes, Mete Ercis, Alessandro Miola, Jorge A Sanchez Ruiz, Gregory Jenkins, Anthony Batzler, Jonathan G Leung, Alfredo Cuellar-Barboza, Susannah J Tye, Susan L McElroy, Joanna M Biernacka, Mark A Frye

There is increasing interest in individualizing treatment selection for more than 25 regulatory approved treatments for major depressive disorder (MDD). Despite an inconclusive efficacy evidence base, antidepressants (ADs) are prescribed for the depressive phase of bipolar disorder (BD) with oftentimes, an inadequate treatment response and or clinical concern for mood destabilization. This study explored the relationship between antidepressant response in MDD and antidepressant-associated treatment emergent mania (TEM) in BD. We conducted a genome-wide association study (GWAS) and polygenic score analysis of TEM and tested its association in a subset of BD-type I patients treated with SSRIs or SNRIs. Our results did not identify any genome-wide significant variants although, we found that a higher polygenic score (PGS) for antidepressant response in MDD was associated with higher odds of TEM in BD. Future studies with larger transdiagnostic depressed cohorts treated with antidepressants are encouraged to identify a neurobiological mechanism associated with a spectrum of depression improvement from response to emergent mania.
© 2024. The Author(s).

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ABOUT THE EXPERTS

Nicolas A Nuñez, Brandon J Coombes, Lindsay Melhuish Beaupre, Aysegul Ozerdem, Manuel Gardea Resendez, Francisco Romo-Nava, David J Bond, Marin Veldic, Balwinder Singh, Katherine M Moore, Hannah K Betcher, Simon Kung, Miguel L Prieto, Manuel Fuentes, Mete Ercis, Alessandro Miola, Jorge A Sanchez Ruiz, Gregory Jenkins, Anthony Batzler, Jonathan G Leung, Alfredo Cuellar-Barboza, Susannah J Tye, Susan L McElroy, Joanna M Biernacka, Mark A Frye

Nicolas A Nuñez

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.

Brandon J Coombes

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Lindsay Melhuish Beaupre

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Aysegul Ozerdem

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.

Manuel Gardea Resendez

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.

Department of Psychiatry, Universidad Autónoma de Nuevo León, Monterrey, México.

Francisco Romo-Nava

Lindner Center of HOPE/University of Cincinnati, Cincinnati, OH, USA.

David J Bond

Department of Psychiatry & Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.

Marin Veldic

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.

Balwinder Singh

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.

Katherine M Moore

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.

Hannah K Betcher

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.

Simon Kung

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.

Miguel L Prieto

Department of Psychiatry, Faculty of Medicine, Universidad de Los Andes, Santiago, Chile.

Manuel Fuentes

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.

Mete Ercis

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.

Alessandro Miola

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.

Jorge A Sanchez Ruiz

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.

Gregory Jenkins

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Anthony Batzler

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Jonathan G Leung

Department of Pharmacy, Mayo Clinic, Rochester, MN, USA.

Alfredo Cuellar-Barboza

Department of Psychiatry, Universidad Autónoma de Nuevo León, Monterrey, México.

Susannah J Tye

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.

Queensland Brain Institute, The University of Queensland, St. Lucia, QLD, Australia.

Susan L McElroy

Lindner Center of HOPE/University of Cincinnati, Cincinnati, OH, USA.

Joanna M Biernacka

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Mark A Frye

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA. mfrye@mayo.edu.