Photo Credit: Sopone Nawoot

The following is a summary of “Comparison of functional outcome after intracerebral hemorrhage in patients with or without end-stage renal disease on hemodialysis: a propensity-score matched study,” published in the November 2024 issue of Neurology by Tsutsumi et al.     

Patients with end-stage renal disease (ESRD) requiring hemodialysis (HD) experience increased mortality after intracerebral hemorrhage (ICH).  

Researchers conducted a retrospective study to examine outcomes in patients with ICH with or without ESRD on HD.  

They conducted a study at the University of California, Irvine Medical Center, between January 1, 2018-July 31, 2022. Patients with ESRD on HD had propensity scores matched to controls. Statistical analyses included logistic regression and area under the curve (AUC) analysis to assess predictors of mortality (P<0.05).  

The results showed 347 patients with ICH, and 24 (6.92%) had ESRD on HD. Compared to patients with non-ESRD, ESRD had higher rates of diabetes mellitus (DM) (79.2% vs. 36.8%, P<0.01) and in-hospital mortality (25% vs. 7.43%, P<0.01). The propensity-score matched analysis confirmed higher in-hospital mortality in the ESRD group (27.3% vs. 8%, P=0.012) and a lower obesity rate (9.1% vs. 34.1%, P=0.02), ESRD status did not affect end-of-life (EOL) care decisions. An ICH score ≥ 3 predicted increased mortality in both groups for ESRD and non-ESRD.  

They concluded that patients with ICH and ESRD on HD had higher in-hospital mortality, suggesting obesity may confer a survival benefit.  

Source: bmcneurol.biomedcentral.com/articles/10.1186/s12883-024-03932-5