PubMed

Evolution of therapeutic management of patients with ANCA associated vasculitis in France after licensing Rituximab use.

Apr 29, 2024

In 2013, rituximab was approved in France for the treatment of ANCA-associated vasculitis (AAV). The aim of the study was to compare the treatment and health events of adult incident patients with granulomatosis with...

Drivers of natural disaster risk-reduction actions and their temporal dynamics: Insights from surveys during an imminent hurricane threat and its aftermath.

Apr 29, 2024

To improve preparedness for natural disasters, it is imperative to understand the factors that enable individual risk-reduction actions. This study offers such insights using innovative real-time (N = 871) and repeated (N = 255)...

The role of fetal therapy in the management of mirror syndrome: a narrative review.

Apr 29, 2024

Mirror syndrome (MS) is a condition characterized by the presence of maternal, fetal, and placental edema and is reversible through delivery or pregnancy termination. As fetal hydrops itself may be amenable to treatment, we...

Real-World Efficacy and Safety of Universal 8-Week Glecaprevir/Pibrentasvir for Treatment-Naïve Patients from a Nationwide HCV Registry in Taiwan.

Apr 29, 2024

Eight-week glecaprevir/pibrentasvir (GLE/PIB) is indicated for treatment-naïve (TN) patients with chronic hepatitis C (CHC), with or without compensated cirrhosis. Given that the Taiwanese government is committed to eliminating...

Presacral Neuroendocrine Neoplasms: A Multi-site Review of Surgical Outcomes.

Apr 29, 2024

Presacral neuroendocrine neoplasms (PNENs) are rare tumors, with limited data on management and outcomes.A retrospective review of institutional medical records was conducted to identify all patients with PNENs between 2008 and...

Expression of inducible nitric oxide synthase, nitrotyrosine, eosinophilic peroxidase, eotaxin-3, and galectin-3 in patients with gastroesophageal reflux disease, eosinophilic esophagitis, and in healthy controls: a semiquantitative image analysis of 3,3′-diaminobenzidine-stained esophageal biopsies.

Apr 29, 2024

Eosinophilic esophagitis (EoE) and gastroesophageal reflux disease (GERD) share many histopathological features; therefore, markers for differentiation are of diagnostic interest and may add to the understanding of the...

Association of serum sclerostin levels with marrow adiposity in postmenopausal women with glucocorticoid-induced osteoporosis.

Apr 29, 2024

Glucocorticoids and sclerostin act as inhibitors of the Wnt signaling pathway, thereby hindering bone formation. Given the pathway’s intricate association with mesenchymal stem cells, the hypothesis suggests that...

Association of stress hyperglycemia ratio and mortality in patients with sepsis: results from 13,199 patients.

Apr 29, 2024

The stress hyperglycemia ratio (SHR), adjusted for average glycemic status, is suggested for assessing actual blood glucose levels. Its link with adverse outcomes is known in certain populations, yet its impact on sepsis...

Short-term outcomes after liver resection with vascular reconstruction: Results from a study with the National Clinical Database of Japan.

Apr 29, 2024

Although curative resection with vascular reconstruction improves the prognosis of blood-invading locally advanced hepatobiliary tumors, the mortality and morbidity of the procedure remains unclear. This study aimed to clarify...

Short-term variation of the fetal heart rate as a marker of intraamniotic infection in pregnancies with preterm prelabor rupture of membranes: a historical cohort study.

Apr 29, 2024

Intraamniotic infection (IAI) and subsequent early-onset neonatal sepsis (EONS) are among the main complications associated with preterm prelabor rupture of membranes (PPROM). Currently used diagnostic tools have been shown to...

In Vitro and In Silico Characterization of the Aggregation of Thrombi on Textured Ventricular Cannula.

Apr 29, 2024

The unacceptably high stroke rate associated with HeartMate 3 ventricular assist device (VAD) without signs of adherent pump thrombosis is hypothesized to be the result of the emboli produced by the inflow cannula, that are...

A review on the nexus of autophagy genes from the perspective of polycystic ovary syndrome.

Apr 29, 2024

Polycystic ovary syndrome or PCOS is an endocrine disorder in women of reproductive age. It is a diversified multi factorial disorder and diagnosis is very complicated because of its overlapping symptoms some of which are...

Awareness of having hypertension, diabetes and dyslipidaemia among US adults: The 2011-2018 NHANES data.

Apr 29, 2024

This study aimed to investigate awareness of having hypertension, diabetes and dyslipidaemia and their associated factors among US adults.Data from the National Health and Nutrition Examination Survey, including 21,399 adults...

A comprehensive history of injection therapy for erectile dysfunction, 1982-2023.

Apr 22, 2024

Although oral phosphodiesterase 5 inhibitors represent a first choice and long-term option for about half of all patients with erectile dysfunction (ED), self-injection therapy with vasoactive drugs remains a viable alternative...

Loss of Independence in Older Adults With Operable Oral Cavity Cancer: A Retrospective Cohort Study.

Apr 22, 2024

To ascertain the effect of curative-intent surgery on loss of independence (LOI) in patients with oral cavity squamous cell carcinoma (OCSCC).Retrospective observational study of patients diagnosed from 2014 to 2021.Single...

Metabolomics-driven discovery of therapeutic targets for cancer cachexia.

Apr 22, 2024

Cancer cachexia (CC) is a devastating metabolic syndrome characterized by skeletal muscle wasting and body weight loss, posing a significant burden on the health and survival of cancer patients. Despite ongoing efforts,...

Impact of income and financial subsidies on oral health care utilization among persons with disabilities in Singapore.

Apr 22, 2024

Globally, studies have shown that the dental disease burden among persons with intellectual and/or developmental disabilities (IDD) is high and can be attributed to lower utilization levels of dental services. The aim of the...

Gender differences in spinal mobility during postural changes: a detailed analysis using upright CT.

Apr 22, 2024

Lumbar spinal alignment is crucial for spine biomechanics and is linked to various spinal pathologies. However, limited research has explored gender-specific differences using CT scans. The objective was to evaluate and compare...

The Long-term Efficacy of Total Knee Arthroplasty on End-stage Kashin-Beck Disease of the Knee in Highland Tibetan Areas Patients: A Retrospective Study with 10-Year Follow-up.

Apr 22, 2024

Despite the established success of total knee arthroplasty (TKA) with end-stage osteoarthritis, there is a notable scarcity of research on its long-term outcomes in individuals suffering from end-stage Kashin-Beck disease (KBD)....

A descriptive study of domestic and family violence presentations to an emergency department in the Northern Territory.

Apr 22, 2024

Examine the nature of domestic and family violence (DFV) presentations to an ED in the Northern Territory and identify potential gaps in service delivery.Prospective descriptive study of DFV presentations in November 2021.A...

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