PubMed

Pembrolizumab plus Chemotherapy in Metastatic Non-Small-Cell Lung Cancer.

Apr 22, 2018

The New England journal of medicine 2018 04 16() doi 10.1056/NEJMoa1801005 Abstract Background First-line therapy for advanced non-small-cell lung cancer (NSCLC) that lacks targetable mutations is platinum-based chemotherapy....

Neoadjuvant PD-1 Blockade in Resectable Lung Cancer.

Apr 22, 2018

The New England journal of medicine 2018 04 16() doi 10.1056/NEJMoa1716078 Abstract Background Antibodies that block programmed death 1 (PD-1) protein improve survival in patients with advanced non-small-cell lung cancer (NSCLC)...

Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden.

Apr 22, 2018

The New England journal of medicine 2018 04 16() doi 10.1056/NEJMoa1801946 Abstract Background...

Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity.

Apr 22, 2018

Nature communications 2018 04 139(1) 1448 doi 10.1038/s41467-018-03927-0 Abstract Off-target DNA...

Adjuvant Pembrolizumab versus Placebo in Resected Stage III Melanoma.

Apr 22, 2018

The New England journal of medicine 2018 04 15() doi 10.1056/NEJMoa1802357 Abstract Background The...

Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals.

Apr 22, 2018

Scientific reports 2018 04 168(1) 6030 doi 10.1038/s41598-018-24463-3 Abstract Aggregation of TAR...

The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates.

Apr 22, 2018

Frontiers in medicine 2018 03 125() 61 doi 10.3389/fmed.2018.00061 Abstract Geroscience, the new...

Oncogenic Signaling Pathways in The Cancer Genome Atlas.

Apr 22, 2018

Cell 173(2) 321-337.e10 pii 10.1016/j.cell.2018.03.035 Abstract Genetic alterations in signaling...

Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling.

Apr 22, 2018

Nature communications 2018 04 139(1) 1466 doi 10.1038/s41467-018-03731-w Abstract To accurately...

A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes.

Apr 22, 2018

Nature communications 2018 04 129(1) 1438 doi 10.1038/s41467-018-03939-w Abstract Autophagy is a...

n-3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease.

Apr 22, 2018

The New England journal of medicine 2018 04 13() doi 10.1056/NEJMoa1709691 Abstract Background Dry...

ATP hydrolysis-dependent disassembly of the 26S proteasome is part of the catalytic cycle.

Apr 22, 2018

Cell 121(4) 553-565 pii 10.1016/j.cell.2005.03.028 Abstract ATP hydrolysis is required for...

A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus.

Apr 22, 2018

Nature communications 2018 04 139(1) 1444 doi 10.1038/s41467-018-03614-0 Abstract The binding of...

Comprehensive Characterization of Cancer Driver Genes and Mutations.

Apr 22, 2018

Cell 173(2) 371-385.e18 pii 10.1016/j.cell.2018.02.060 Abstract Identifying molecular cancer...

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples.

Apr 22, 2018

Cell 173(2) 386-399.e12 pii 10.1016/j.cell.2018.03.027 Abstract The role of enhancers, a key class of non-coding regulatory DNA elements, in cancer development has increasingly been appreciated. Here, we present the detection...

Effectiveness and Safety of Apixaban, Dabigatran, and Rivaroxaban Versus Warfarin in Frail Patients With Nonvalvular Atrial Fibrillation.

Apr 22, 2018

Journal of the American Heart Association 2018 04 137(8) pii 10.1161/JAHA.118.008643 Abstract BACKGROUND Frailty predicts poorer outcomes and decreased anticoagulation use in patients with nonvalvular atrial fibrillation. We...