PubMed

Frontiers in oncology 2018 05 248() 161 doi 10.3389/fonc.2018.00161 Abstract Advances in chemotherapy and targeted therapies have improved survival in cancer patients with an increase of the incidence of newly diagnosed brain...

PLoS biology 2018 07 1616(7) e2005840 doi 10.1371/journal.pbio.2005840 Abstract Clustered, regularly interspaced, short palindromic repeat (CRISPR)-CRISPR-associated 9 (Cas9) genome editing is revolutionizing fundamental...

Nature communications 2018 07 139(1) 2724 doi 10.1038/s41467-018-05072-0 Abstract Identifying tumor antigen-specific T cells from cancer patients has important implications for immunotherapy diagnostics and therapeutics. Here,...

Genome biology 2018 07 1219(1) 88 doi 10.1186/s13059-018-1464-7 Abstract BACKGROUND DNA methylation is a heritable epigenetic mark, enabling stable but reversible gene repression. In mammalian cells, DNA methyltransferases...

Molecular cell 2018 06 2871(1) 56-72.e4 pii 10.1016/j.molcel.2018.06.003 Abstract Chromatin remodeling complexes play essential roles in metazoan development through widespread control of gene expression, but the precise...

Evidence-based complementary and alternative medicine : eCAM 2018 06 072018() 9521086 doi 10.1155/2018/9521086 Abstract Showering is the most common form of bathing worldwide. Whole-body immersion bathing in warm water (~40°C)...

Cell 173(2) 278-280 doi 10.1016/j.cell.2018.03.047 Abstract

Tropical medicine & international health : TM & IH 2011 10 0417(1) 135-8 doi 10.1111/j.1365-3156.2011.02885.x Abstract OBJECTIVE Internal use of ‘camphor’ is a potential public health concern in Accra. We...

Cell reports 24(2) 429-440 pii 10.1016/j.celrep.2018.06.042 Abstract Mycobacterium tuberculosis (Mtb) kills infected macrophages by inhibiting apoptosis and promoting necrosis. The tuberculosis necrotizing toxin (TNT) is a...

The New England journal of medicine 379(2) 138-149 doi 10.1056/NEJMoa1714021 Abstract BACKGROUND Recent Mycobacterium tuberculosis infection confers a predisposition to the development of tuberculosis disease, the leading killer...

Cell reports 24(2) 320-328 pii 10.1016/j.celrep.2018.06.047 Abstract The flavivirus genus comprises major human pathogens, such as Dengue (DENV) and Zika (ZIKV) viruses. RIG-I and MDA5 are key cytoplasmic pathogen recognition...

Neurobiology of stress 2018 05 199() 9-21 doi 10.1016/j.ynstr.2018.05.003 Abstract Microglia are the predominant immune cells of the central nervous system (CNS) that exert key physiological roles required for maintaining CNS...

Nature communications 2018 07 069(1) 2643 doi 10.1038/s41467-018-05067-x Abstract CRISPR-Cas9-based gene activation (CRISPRa) is an attractive tool for cellular reprogramming applications due to its high multiplexing capacity...

Journal of the International Society of Sports Nutrition 2018 07 0915(1) 31 doi 10.1186/s12970-018-0236-9 Abstract BACKGROUND Ketogenic diets (KD) have become a popular method of promoting weight loss. More recently, some have...

Nature communications 2018 07 069(1) 2641 doi 10.1038/s41467-018-05073-z Abstract RNA-based drugs depend on chemical modifications to increase potency and to decrease immunogenicity in vivo. Chemical modification will likely...

Cancer science 2018 07 07() doi 10.1111/cas.13726 Abstract Recent years have seen a number of regulatory approvals for immune oncology or immunotherapies based on their ability to enhance anti-tumor immune responses....

Acta neuropathologica communications 2018 07 046(1) 55 doi 10.1186/s40478-018-0555-8 Abstract A hexanucleotide (GGGGCC) repeat expansion in C9ORF72 is the most common genetic contributor to amyotrophic lateral sclerosis (ALS)...

Nature communications 2018 06 309(1) 2447 doi 10.1038/s41467-018-04907-0 Abstract Signet-ring cell carcinoma (SRCC) has specific epidemiology and oncogenesis in gastric cancer, however, with no systematical investigation for...

eLife 2018 07 037() doi 10.7554/eLife.36402 Abstract Parkinson’s disease is a progressive neuropathological disorder that belongs to the class of synucleopathies, in which the protein alpha-synuclein is found at abnormally...

The New England journal of medicine 2018 05 22() doi 10.1056/NEJMoa1803538 Abstract Background We hypothesized that fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) would be superior to medical...