PubMed

Nature 2018 07 18() doi 10.1038/s41586-018-0342-5 Abstract Acute lymphoblastic leukaemia (ALL) has a marked propensity to metastasize to the central nervous system (CNS). In contrast to brain metastases from solid tumours,...

Science translational medicine 10(450) pii 10.1126/scitranslmed.aar3342 Abstract Combination anti-cytotoxic T lymphocyte antigen 4 (CTLA-4) and anti-programmed cell death protein 1 (PD-1) therapy promotes antitumor immunity and...

Nature methods 2018 07 16() doi 10.1038/s41592-018-0048-5 Abstract The RNA-guided endonuclease Cas9 can be converted into a programmable transcriptional repressor, but inefficiencies in target-gene silencing have limited its...

Nature communications 2018 06 309(1) 2447 doi 10.1038/s41467-018-04907-0 Abstract Signet-ring cell carcinoma (SRCC) has specific epidemiology and oncogenesis in gastric cancer, however, with no systematical investigation for...

eLife 2018 07 037() doi 10.7554/eLife.36402 Abstract Parkinson’s disease is a progressive neuropathological disorder that belongs to the class of synucleopathies, in which the protein alpha-synuclein is found at abnormally...

Genes & development 2018 06 2732(13-14) 929-943 doi 10.1101/gad.313932.118 Abstract While a mutation in is the most common genetic contributor to amyotrophic lateral sclerosis (ALS), much remains to be learned concerning...

The New England journal of medicine 2018 06 25() doi 10.1056/NEJMoa1805233 Abstract Background In patients with diabetes, hospitalization can complicate the achievement of recommended glycemic targets. There is increasing...

The New England journal of medicine 2018 06 26() doi 10.1056/NEJMoa1716435 Abstract Background The prognosis of patients with recurrent World Health Organization (WHO) grade IV malignant glioma is dismal, and there is currently...

Cell 2018 06 13() pii 10.1016/j.cell.2018.05.047 Abstract The inner nuclear membrane (INM) encases the genome and is fused with the outer nuclear membrane (ONM) to form the nuclear envelope. The ONM is contiguous with the...

The Journal of clinical investigation 2018 06 26() doi 10.1172/JCI96393 Abstract Dormant or slow-cycling tumour cells can form a residual chemoresistant reservoir responsible for relapse in patients, years after curative surgery...

Cell 2018 06 12() pii 10.1016/j.cell.2018.05.039 Abstract Many community- and hospital-acquired bacterial infections are caused by antibiotic-resistant pathogens. Methicillin-resistant Staphylococcus aureus (MRSA) predisposes...

The New England journal of medicine 2018 06 13378(25) 2441-2442 doi 10.1056/NEJMc1806491 Abstract

Cell 2018 06 09() pii 10.1016/j.cell.2018.05.057 Abstract The diversity of cell types and regulatory states in the brain, and how these change during aging, remains largely unknown. We present a single-cell transcriptome atlas...

Sports (Basel, Switzerland) 2018 01 096(1) pii 10.3390/sports6010001 Abstract Adopting low carbohydrate, ketogenic diets remains a controversial issue for individuals who resistance train given that this form of dieting has been...

eLife 2018 06 127() doi 10.7554/eLife.33246 Abstract Mitochondrial NAD levels influence fuel selection, circadian rhythms, and cell survival under stress. It has alternately been argued that NAD in mammalian mitochondria arises...

Proceedings of the National Academy of Sciences of the United States of America 2018 06 11115(26) 6822-6827 doi 10.1073/pnas.1806308115 Abstract Novel reassortant avian influenza H7N9 virus and pandemic 2009 H1N1 (H1N1pdm) virus...

Nature communications 2018 06 069(1) 2197 doi 10.1038/s41467-018-04564-3 Abstract Eukaryotic cells employ the ribosome-associated quality control complex (RQC) to maintain homeostasis despite defects that cause ribosomes to...

PloS one 2018 06 1813(6) e0198166 doi 10.1371/journal.pone.0198166 Abstract Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP)...

International journal of molecular sciences 2018 06 0619(6) pii 10.3390/ijms19061689 Abstract Parkinson’s disease (PD) is a progressively debilitating neurodegenerative disease characterized by α-synucleinopathy,...

Nature communications 2018 06 089(1) 2231 doi 10.1038/s41467-018-04651-5 Abstract CRISPR advances genome engineering by directing endonuclease sequence specificity with a guide RNA molecule (gRNA). For precisely targeting a gene...