PubMed

The New England journal of medicine 379(7) 633-644 doi 10.1056/NEJMoa1800256 Abstract BACKGROUND Patients with diabetes are at higher risk for death and cardiovascular outcomes than the general population. We investigated...

The New England journal of medicine 379(7) 623-632 doi 10.1056/NEJMoa1803626 Abstract BACKGROUND Whether weight gain after smoking cessation attenuates the health benefits of quitting is unclear. METHODS In three cohort studies...

The New England journal of medicine 379(7) 645-654 doi 10.1056/NEJMoa1711460 Abstract BACKGROUND Ibalizumab, a humanized IgG4 monoclonal antibody, blocks the entry of human immunodeficiency virus type 1 (HIV-1) by noncompetitive...

Blood 2018 07 06132(7) 707-716 doi 10.1182/blood-2018-03-837153 Abstract The need to accurately identify cancer outpatients at high risk of thrombotic complications is still unmet. In a prospective, multicenter cohort study...

Science (New York, N.Y.) 2018 07 05361(6403) 704-709 doi 10.1126/science.aat1022 Abstract The binding of DNA to cyclic GMP-AMP synthase (cGAS) leads to the production of the secondary messenger cyclic GMP-AMP (cGAMP), which...

Nature 2018 07 18559(7715) 637-641 doi 10.1038/s41586-018-0350-5 Abstract Diabetes is a complex metabolic syndrome that is characterized by prolonged high blood glucose levels and frequently associated with life-threatening...

Blood 2018 07 18() pii 10.1182/blood-2017-12-823393 Abstract

Nature cell biology 2018 07 1820(8) 954-965 doi 10.1038/s41556-018-0140-1 Abstract BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP)...

Nature genetics 2018 07 18() doi 10.1038/s41588-018-0169-x Abstract In the version of this article originally published, in the "Theoretical framework of subclonal selection" section of the main text, ref. 11 instead...

JAMA 2018 07 16() doi 10.1001/jama.2018.8401 Abstract

Drugs 2018 07 21() doi 10.1007/s40265-018-0954-y Abstract The article Andexanet Alfa: First Global Approval, written by Young-A Heo, was originally published Online First without open access.

Nature communications 2018 07 189(1) 2794 doi 10.1038/s41467-018-05273-7 Abstract Mutations in proteins like FUS which cause Amyotrophic Lateral Sclerosis (ALS) result in the aberrant formation of stress granules while...

Nature biotechnology 2018 07 16() doi 10.1038/nbt.4192 Abstract CRISPR-Cas9 is poised to become the gene editing tool of choice in clinical contexts. Thus far, exploration of Cas9-induced genetic alterations has been limited to...

Nature 2018 07 18() doi 10.1038/s41586-018-0324-7 Abstract In DNA repair, the resection of double-strand breaks dictates the choice between homology-directed repair-which requires a 3′ overhang-and classical non-homologous...

Cancer immunology research 2018 07 20() pii 10.1158/2326-6066.CIR-17-0405 Abstract The success of chimeric antigen receptor (CAR)-mediated immunotherapy in acute lymphoblastic leukemia (ALL) highlights the potential of T-cell...

Nature 2018 07 18() doi 10.1038/s41586-018-0353-2 Abstract Thermogenesis by brown and beige adipose tissue, which requires activation by external stimuli, can counter metabolic disease. Thermogenic respiration is initiated by...

Cellular and molecular gastroenterology and hepatology 2018 04 126(2) 133-148 doi 10.1016/j.jcmgh.2018.04.003 Abstract Preclinical and clinical studies have shown bidirectional interactions within the brain-gut-microbiome axis....

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2018 07 19() JCO2017776112 doi 10.1200/JCO.2017.77.6112 Abstract Purpose CPX-351 is a dual-drug liposomal encapsulation of cytarabine...

Nature communications 2018 07 209(1) 2845 doi 10.1038/s41467-018-05049-z Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share key features, including accumulation of the RNA-binding protein...

Nature 559(7714) 336-338 doi 10.1038/d41586-018-05679-9 Abstract