PubMed

Cell reports 26(6) 1544-1556.e8 pii 10.1016/j.celrep.2019.01.043 Abstract The tripeptide glutathione suppresses the iron-dependent, non-apoptotic cell death process of ferroptosis. How glutathione abundance is regulated in the...

Frontiers in genetics 2019 01 229() 712 doi 10.3389/fgene.2018.00712 Abstract Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease and is characterized by the degeneration of upper and lower...

Cell reports 26(6) 1585-1597.e4 pii 10.1016/j.celrep.2019.01.052 Abstract Spondweni virus (SPOV) is the flavivirus that is most closely related to Zika virus (ZIKV). Although SPOV causes sporadic human infections in Africa,...

Advances in nutrition (Bethesda, Md.) 10(suppl_1) S31-S48 doi 10.1093/advances/nmy037 Abstract The consumption of sugar-free foods is growing because of their low-calorie content and the health concerns about products with high...

Genome biology 2018 10 0819(1) 160 doi 10.1186/s13059-018-1531-0 Abstract BACKGROUND Recent genome-wide association studies (GWAS) have identified more than 100 loci associated with increased risk of prostate cancer, most of...

Proceedings of the National Academy of Sciences of the United States of America 2018 10 08() pii 10.1073/pnas.1802166115 Abstract Programmed death-ligand 1 (PD-L1) expression on tumor cells (TCs) by immunohistochemistry is...

JCI insight 2018 10 043(19) doi 10.1172/jci.insight.122467 Abstract Adoptive cell transfer (ACT) of tumor-infiltrating lymphocytes (TILs) targeting neoantigens can mediate tumor regression in selected patients with metastatic...

The New England journal of medicine 2018 09 25() doi 10.1056/NEJMoa1809064 Abstract BACKGROUND Enhancing tumor-specific T-cell immunity by inhibiting programmed death ligand 1 (PD-L1)-programmed death 1 (PD-1) signaling has...

The New England journal of medicine 2018 09 25() doi 10.1056/NEJMoa1810865 Abstract BACKGROUND Standard first-line therapy for metastatic, squamous non-small-cell lung cancer (NSCLC) is platinum-based chemotherapy or...

The New England journal of medicine 2018 10 01() doi 10.1056/NEJMe1812434 Abstract

Biomedical journal 38(1) 5-8 doi 10.4103/2319-4170.151150 Abstract The first Tang Prize for Biopharmaceutical Science has been awarded to Prof. James P. Allison and Prof. Tasuku Honjo for their contributions leading to an...

The New England journal of medicine 2018 09 25() doi 10.1056/NEJMoa1809697 Abstract BACKGROUND An earlier analysis in this phase 3 trial showed that durvalumab significantly prolonged progression-free survival, as compared with...

EBioMedicine 2018 09 29() pii 10.1016/j.ebiom.2018.09.015 Abstract BACKGROUND Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated...

The New England journal of medicine 2018 09 25() doi 10.1056/NEJMoa1810171 Abstract BACKGROUND Brigatinib, a next-generation anaplastic lymphoma kinase (ALK) inhibitor, has robust efficacy in patients with ALK-positive...

Cell reports 25(1) 80-94 pii 10.1016/j.celrep.2018.09.012 Abstract We examined hematopoietic protein kinase 1 (HPK1), whose reliance on scaffold versus kinase functions for negative immune cell regulation is poorly understood...

Cells 2018 10 017(10) pii 10.3390/cells7100155 Abstract Patient derived anti-CD19 chimeric antigen receptor-T (CAR-T) cells are a powerful tool in achieving a complete remission in a range of B-cell malignancies, most notably...

Clinical & developmental immunology 2012 03 262012() 485781 doi 10.1155/2012/485781 Abstract The immune system has evolved to allow robust responses against pathogens while avoiding autoimmunity. This is notably enabled by...

Angewandte Chemie (International ed. in English) 2017 11 2857(16) 4143-4148 doi 10.1002/anie.201708408 Abstract Tailor-made: Discussed herein is the ability to adapt biology’s mechanisms for innovation and optimization to...

Proceedings of the National Academy of Sciences of the United States of America 90(12) 5618-22 Abstract Random mutagenesis has been used to engineer the protease subtilisin E to function in a highly nonnatural...

Sports medicine (Auckland, N.Z.) 44 Suppl 2() S175-84 doi 10.1007/s40279-014-0257-8 Abstract Caffeine is a popular work-enhancing supplement that has been actively researched since the 1970s. The majority of research has...