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Critical Care General

Tau aggregation and increased neuroinflammation in athletes after sports-related concussions and in traumatic brain injury patients - A PET/MR study.

Apr 26, 2021

Traumatic brain injury (TBI) and repeated sports-related concussions (rSRCs) are associated with an increased risk for neurodegeneration. Autopsy findings of selected cohorts of long-term TBI survivor...

Potential anti-inflammatory effect of erythropoietin in non-clinical studies in vivo: A systematic review.

Apr 26, 2021

Erythropoietin (EPO) is a hypoxia-induced hormone produced in adult kidneys with erythropoietic and non-erythropoietic effects. In vivo studies represent an important role to comprehend the efficacy a...

"Determinants of treatment modification before and after implementation of the updated 2015 NICE guideline on type 2 diabetes: a retrospective cohort study".

Apr 26, 2021

To identify patient-specific factors associated with early metformin treatment modification among type 2 diabetes patients before and after implementation of the updated 2015 NICE (National Institute ...

Changes in Pediatric ICU Utilization and Clinical Trends During the Coronavirus Pandemic.

Apr 26, 2021

Children have been less affected by the COVID-19 pandemic, but its repercussions on pediatric illnesses may have been significant. This study examines the indirect impact of the pandemic on a populati...

The Impacts of Statin Use on Physical Function in Men With & Without HIV

Apr 23, 2021

With an increasing prevalence of older adults living with HIV, thanks to the effectiveness of ART, so too has the prevalence of age-related chronic illnesses—including cardiovascular disease (CVD)...

Alberta Stroke Program Early CT Score Calculation Using the Deep Learning-Based Brain Hemisphere Comparison Algorithm.

Apr 22, 2021

The Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is a promising tool for the evaluation of stroke expansion to determine suitability for reperfusion therapy. The aim of this study ...

25-Hydroxycholesterol mitigates hepatic ischemia reperfusion injury via mediating mitophagy.

Apr 22, 2021

Hepatic ischemia reperfusion (I/R) injury remains a major obstacle in liver transplantation, however an effective treatment to mitigate this injury is lacking. 25-Hydroxycholesterol (25HC) is a kind o...

Latency Period after Preterm Premature Rupture of Membranes: Singletons versus Twins.

Apr 22, 2021

 Several studies have evaluated the differences in duration of latency and clinical outcomes between singleton and twin pregnancies after preterm premature rupture of membranes (PPROM); however, the...

Altered Fibrinolysis during and after Surgery.

Apr 22, 2021

Major surgery induces hemostatic changes related to surgical stress, tissue destruction, and inflammatory reactions. These changes involve a shift of volume from extravascular space to intravascular a...

Identifying prognostic factors and developing accurate outcome predictions for in-hospital cardiac arrest by using artificial neural networks.

Apr 22, 2021

Accurate estimation of neurological outcomes after in-hospital cardiac arrest (IHCA) provides crucial information for clinical management. This study used artificial neural networks (ANNs) to determin...

Low Prevalence of Antibodies to SARS-CoV-2 and Undetectable Viral Load in Seropositive Blood Donors from South-Eastern Italy.

Apr 22, 2021

Recently, a significant cluster of pneumonia caused by a novel betacoronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) was described initially in China and then spread throughout...

Clinical and Demographic Risk Factors for COVID-19 during Delivery Hospitalizations in New York City.

Apr 22, 2021

 This study was aimed to review 4 weeks of universal novel coronavirus disease 2019 (COVID-19) screening among delivery hospitalizations, at two hospitals in March and April 2020 in New York City, t...

SAS CARE 2 - a randomized study of CPAP in patients with obstructive sleep disordered breathing following ischemic stroke or transient ischemic attack.

Apr 22, 2021

The benefit of Continuous Positive Airway Pressure (CPAP) treatment following ischemic stroke in patients with obstructive sleep-disordered breathing (SDB) is unclear. We set out to investigate this o...

[Causes of death and influencing factors of atrial fibrillation patients undergoing anticoagulation therapy].

Apr 22, 2021

To investigate the causes of death and predictors in patients with nonvalvular atrial fibrillation (AF) undergoing anticoagulation therapy. Consecutive anticoagulated nonvalvular AF patients were re...

Fibrinolytic Alterations in Sepsis: Biomarkers and Future Treatment Targets.

Apr 22, 2021

Sepsis is a life-threatening condition which develops as a dysregulated immune response in the face of infection and which is associated with profound hemostatic disturbances and in the most extreme c...

Rule Modifications to Reduce Checking-Related Injuries in High School Boys' Lacrosse.

Apr 22, 2021

The National Federation of State High School Associations previously implemented 2 lacrosse rule modifications: Rule 5.4 in the 2012-2013 academic year to heighten the penalty for a head or neck hit t...

Fibrinolysis in Traumatic Brain Injury: Diagnosis, Management, and Clinical Considerations.

Apr 22, 2021

Posttraumatic coagulopathy involves disruption of both the coagulation and fibrinolytic pathways secondary to tissue damage, hypotension, and inflammatory upregulation. This phenomenon contributes to ...

Tranexamic Acid Treatment for Trauma Victims.

Apr 22, 2021

Worldwide, traumatic injury is responsible for over 5 million deaths per year, the majority due to exsanguination and head injury. The antifibrinolytic drug tranexamic acid is the only drug proven to ...

Clinical and economic outcomes of a collaborative cardiology care program.

Apr 22, 2021

We evaluated a collaborative care program aimed at improving cooperation among general practitioners (GPs) and cardiologists in Baden-Wuerttemberg, Germany. The program focused on improving care for p...

Hematocrit-Related Alterations of Circulating microRNA-21 Levels in Heart Failure Patients with Reduced Ejection Fraction: A Preliminary Study.

Apr 22, 2021

Circulating microRNA-21 (miR-21) has been utilized as a diagnostic tool in the assessment of heart failure (HF). Blood constitution may be altered when HF occurs and miR-21 may affect hematopoiesis. ...

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