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Critical Care General

COVID-19 patients' sera induce epithelial mesenchymal transition in cancer cells.

Jun 07, 2021

Covid-19 Pneumonia of SARS-CoV-2 pandemic infection, persists to have high disease burden especially in cancer patients. Increased inflammation and thromboembolic processes are blamed to influence can...

Use of post-mortem chest computed tomography in Covid-19 pneumonia.

Jun 07, 2021

COVID-19 is an extremely challenging disease, both from a clinical and forensic point of view, and performing autopsies of COVID-19 deceased requires adequately equipped sectorial rooms and exposes he...

MENINGO-ENCEPHALITIS IN A MIDDLE-AGED WOMAN HOSPITALIZED FOR COVID-19.

Jun 07, 2021

The aim: To pay attention of clinicians to possible lesions of the central nervous system (encephalitis) in patients with COVID-19.Case presentation: A 44-year-old woman was admitted to our clinic bec...

Cardiovascular risk prediction in type 2 diabetes before and after widespread screening: a derivation and validation study.

Jun 07, 2021

Until recently, most patients with diabetes worldwide have been diagnosed when symptomatic and have high cardiovascular risk, meaning most should be prescribed cardiovascular preventive medications. H...

Association of Initial Potassium Levels with the Type of Stroke in the Emergency Department.

Jun 03, 2021

Serum potassium levels are considered as a marker of cerebrovascular emergencies but there is less clarity on the association between initial serum potassium levels recorded on patient's arrival at th...

Emerging Concepts in Vascular Dementia: A Review.

Jun 03, 2021

Vascular dementia (VaD) is the second most common cause of dementia and a major health concern worldwide. A comprehensive review on VaD is warranted for better understanding and guidance for the pract...

Diagnosis and management of acute lower gastrointestinal bleeding: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.

Jun 03, 2021

1: ESGE recommends that the initial assessment of patients presenting with acute lower gastrointestinal bleeding should include: a history of co-morbidities and medications that promote bleeding; hemo...

Stress and the Gut-Brain Axis: Implications for Cancer, Inflammation and Sepsis.

Jun 03, 2021

The gut-brain axis has been discussed, directly or indirectly, for centuries, with the ideas of the gut affecting anything from moods to overall physiology being discussed across the centuries. With a...

BAM15, a Mitochondrial Uncoupling Agent, Attenuates Inflammation in the LPS Injection Mouse Model: An Adjunctive Anti-Inflammation on Macrophages and Hepatocytes.

Jun 03, 2021

Controlof immune responses through the immunometabolism interference is interesting for sepsis treatment. Then, expression of immunometabolism-associated genes and BAM15, a mitochondrial uncoupling ag...

Lesson learned from the 2017 measles outbreak in Italy: report from an emergency department.

Jun 03, 2021

Measles is a preventable disease still responsible for a number of outbreaks worldwide. Although most adults with measles recover uneventfully, measles-related complications may occur. However, as to ...

IL-4 protects mice against lethal influenza and Streptococcus pneumoniae co-infected pneumonia.

Jun 03, 2021

Streptococcus pneumoniae (S. pneumoniae) co-infection post influenza is a major cause of mortality characterized by uncontrolled bacteria burden and excessive immune response during influenza pandemic...

Respiratory bacterial co-infections in intensive care unit-hospitalized COVID-19 patients: Conventional culture vs BioFire FilmArray pneumonia Plus panel.

Jun 03, 2021

The prevalence and microbiology of concomitant respiratory bacterial infections in patients with SARS-CoV-2 infection are not yet fully understood. In this retrospective study, we assessed respiratory...

High-sensitivity troponin assays for early rule-out of acute myocardial infarction in people with acute chest pain: a systematic review and economic evaluation.

Jun 03, 2021

Early diagnosis of acute myocardial infarction is important, but only 20% of emergency admissions for chest pain will actually have an acute myocardial infarction. High-sensitivity cardiac troponin as...

Pegylated liposomal doxorubicin as first line treatment in aids-related Kaposi's sarcoma: a real-life study.

Jun 03, 2021

Despite the introduction of effective combination antiretroviral therapy (cART) AIDS-related Kaposi Sarcoma (AIDS-KS) remains the most common malignancy in HIV positive patients. In advanced stage or ...

Folic acid alleviates the blood brain barrier permeability and oxidative stress and prevents cognitive decline in sepsis-surviving rats.

Jun 03, 2021

Sepsis is a complication of an infection which imbalance the normal regulation of several organ systems, including the central nervous system (CNS). Evidence points towards inflammation and oxidative ...

The Association between Pathologic Complete Response after Neoadjuvant Chemoradiotherapy and Postoperative Complications.

Jun 03, 2021

With growing interest in the watch-and-wait strategy, the benefits of avoiding surgery and its complications must be weighed against possible recurrence and need for salvage surgery. However, the rela...

The Role of Thyroid Hormone in Neuronal Protection.

Jun 03, 2021

Thyroid hormone is essential for brain development and brain function in the adult. During development, thyroid hormone acts in a spatial and temporal-specific manner to regulate the expression of gen...

The relationship between brain injury criteria and brain strain across different types of head impacts can be different.

Jun 03, 2021

Multiple brain injury criteria (BIC) are developed to quickly quantify brain injury risks after head impacts. These BIC originated from different head impact types (e.g. sports and car crashes) are wi...

Wakefulness-promoting effects of lateral hypothalamic area deep brain stimulation in traumatic brain injury-induced comatose rats: Upregulation of α1-adrenoceptor subtypes and downregulation of gamma-aminobutyric acid b receptor expression via the orexins pathway.

Jun 03, 2021

Previous studies have shown that deep brain stimulation can improve the levels of consciousness of comatose patients with traumatic brain injuries (TBIs). However, the most suitable targets for deep b...

Complex functionality of protein phosphatase 1 isoforms in the heart.

Jun 03, 2021

Protein phosphatase 1(PP1) is a key regulator of cardiac function through dephosphorylating serine/threonine residues within target proteins to oppose the function of protein kinases. Studies from fai...

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