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Critical Care General

Associations between low body mass index and mortality in patients with sepsis: A retrospective analysis of a cohort study in Japan.

Jun 10, 2021

The distribution of body mass in populations of Western countries differs from that of populations of East Asian countries. In East Asian countries, fewer people have a high body mass index than those...

Analysis of the diagnostic capabilities of urinary neutrophil gelatinase-associated lipocalin and serum procalcitonin for acute kidney injury at the early stage of critical care intensive care unit admission.

Jun 10, 2021

Acute kidney injury (AKI) is a disease that negatively affects patient prognosis and requires early diagnosis and treatment. Biomarkers that predict AKI are needed for early diagnosis of this disease....

Airway Administration of Flagellin Regulates the Inflammatory Response to .

Jun 10, 2021

Excessive lung inflammation and airway epithelium damage are hallmarks of human inflammatory lung diseases, such as cystic fibrosis (CF). Enhancement of innate immunity provides protection against pat...

An Open-label, Single-arm, Multicenter Study of Ibrutinib in Japanese Patients With Steroid-dependent/Refractory Chronic Graft-Versus-Host Disease.

Jun 10, 2021

Chronic graft-versus-host disease (cGVHD) is a serious complication after allogeneic stem cell transplantation. There are no well-established treatment options for cGVHD after primary steroid-based tr...

Dual attention multiple instance learning with unsupervised complementary loss for COVID-19 screening.

Jun 10, 2021

Chest computed tomography (CT) based analysis and diagnosis of the Coronavirus Disease 2019 (COVID-19) plays a key role in combating the outbreak of the pandemic that has rapidly spread worldwide. To ...

Bee Attack or Heart Attack: Kounis Syndrome.

Jun 10, 2021

Kounis syndrome (KS) is defined as an allergic or hypersensitivity reaction leading to coronary vasospasm and acute coronary syndrome. The inflammatory mediators released during the body's reaction to...

Stroke and cardiovascular risk factors among working-aged Finnish migraineurs.

Jun 10, 2021

The aim of our study was to evaluate the risk for comorbid cardio- and cerebrovascular diseases in the working-aged migraine population of Finland.A total of 1505 cases who reported diagnosed migraine...

Prevalence and influencing factors of chronic post-traumatic stress disorder in patients with myocardial infarction, transient ischemic attack (TIA) and stroke - an exploratory, descriptive study.

Jun 10, 2021

Cardio- and cerebrovascular events such as myocardial infarction (MI), stroke and transient ischemic attack (TIA) are leading causes of death and disability and have also been associated with poor men...

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection.

Jun 10, 2021

Age is the dominant risk factor for infectious diseases, but the mechanisms linking age to infectious disease risk are incompletely understood. Age-related mosaic chromosomal alterations (mCAs) detect...

New perspectives for mesenchymal stromal cells as an adjuvant therapy for infectious disease-associated encephalopathies.

Jun 10, 2021

Knowledge of the mechanisms that trigger infection-related encephalopathies is still very limited and cell therapies are one of the most promising alternatives for neurodegenerative diseases, and its ...

Recent increase in incidence of invasive serogroup W meningococcal disease. A retrospective observational study.

Jun 10, 2021

Neisseria meningitidis serogroup W incidence has increased. Mortality associated with serogroup W has been higher than for other serogroups. Here we report epidemiological characteristics and risks of...

Golf cart injuries in children: the experience of trauma centers in a single state in the USA.

Jun 10, 2021

Golf carts remain a source of morbidity in children. We aimed to establish the incidence and injury characteristics of pediatric patients injured due to golf cart usage over an 11-year period. This is...

Serum calprotectin as a prognostic predictor in severe traumatic brain injury.

Jun 10, 2021

Calprotectin plays an important role during inflammation. We intended to explore the prognostic value of serum calprotectin levels in patients with severe traumatic brain injury (sTBI).In this prospec...

SIRT2 inhibition exacerbates p53-mediated ferroptosis in mice following experimental traumatic brain injury.

Jun 10, 2021

Ferroptosis plays an important role in traumatic brain injury (TBI). The p53 protein is a major mediator of ferroptosis. However, the role of p53-mediated ferroptosis in TBI has not been studied. Sirt...

Metagenomic analysis of gut microbiota reveals its role in trimethylamine metabolism in heart failure.

Jun 10, 2021

We had previously reported an increase in trimethylamine N-oxide (TMAO) levels in patients with both compensated and decompensated heart failure (HF) and alteration in gut microbiota composition using...

Cerebral Structure and Function in Stroke-free Patients with Atrial Fibrillation.

Jun 10, 2021

Atrial fibrillation (AF) is associated with high risk of dementia and brain atrophy in stroke-free patients, but the mechanisms underlying this association remain unclear. We aimed to examine the brai...

COVID-19: Autopsy findings in six patients between 26 and 46 years of age.

Jun 07, 2021

Studies on the coronavirus disease 2019 (COVID-19) usually focus on middle aged and older adults. However, younger patients may present with severe COVID-19 and potentially fatal outcomes. For optimiz...

New mechanisms of ginseng saponin-mediated anti-inflammatory action via targeting canonical inflammasome signaling pathways.

Jun 07, 2021

Ginseng is an ethnopharmacological herbal plant in Asian countries, particularly in Korea, China, and Japan. Ginseng saponins, including ginsenosides, are major active components in ginseng and have b...

Vasopressor and inotrope treatment for septic shock: An umbrella review of reviews.

Jun 07, 2021

To review the characteristics, findings and quality of systematic reviews (SRs) on the effect of any vasopressor/inotrope on outcomes in adult patients with sepsis compared with either no treatment, a...

High-grade intradiverticulum bladder tumor: A case report.

Jun 07, 2021

Bladder diverticula are mucosal outpunching of the bladder without a muscle layer. It could be detected incidentally or by giving symptoms of its complications.A 59-year-old male patient presented wit...

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