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Critical Care General

Bioguided isolation, identification and bioactivity evaluation of anti-MRSA constituents from Morus alba Linn.

Aug 26, 2021

The root bark of Morus alba Linn. (M. alba), a traditional folk medicine, has been documented in the Chinese Pharmacopoeia, which has been widely used for asthma, fever, pneumonia, edema, vomit, colit...

Pharmacokinetic/Pharmacodynamic Modeling to Evaluate the Efficacy of Various Dosing Regimens of Ceftazidime/Avibactam in Patients With Pneumonia Caused by Klebsiella pneumoniae Carbapenemase-producing K. pneumoniae: a multicenter study in northern China.

Aug 26, 2021

The objective of our study was to evaluate the efficacy of different dosing regimens of ceftazidime/avibactam (CZA) in patients with Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp...

Long-Term Ticagrelor in Patients With Prior Coronary Stenting in the PEGASUS-TIMI 54 Trial.

Aug 26, 2021

Background Coronary stent type and risk of stent thrombosis remain important factors affecting recommended duration of dual antiplatelet therapy. We investigated the efficacy and safety of long-term t...

Psychological changes after coronary angiographic intervention: pre-post comparison and follow-up.

Aug 26, 2021

Epidemiological studies demonstrate the relevance of cardiovascular diseases for health policies and medical care, especially coronary heart diseases and myocardial infarction. Research has shown that...

[Urachal patency in neonatal foals - a review of the literature].

Aug 26, 2021

Urachal patency is an umbilical disease in newborn foals. Etiologically, either the closure of the urachus remains absent after birth (persistent urachus) or the urachus was already closed and reopens...

A comparison of predictors for mortality and bacteraemia in patients suspected of infection.

Aug 26, 2021

Stratification by clinical scores of patients suspected of infection can be used to support decisions on treatment and diagnostic workup. Seven clinical scores, SepsisFinder (SF), National Early Warni...

Non-classical monocytes and its potential in diagnosing sepsis post cardiac surgery.

Aug 26, 2021

Sepsis is caused by a dysregulation of immune response to infection that results in very high mortality. Current laboratory tests and clinical criteria are inadequate to diagnose sepsis due to limited...

Aging impairs the essential contributions of non-glial progenitors to neurorepair in the dorsal telencephalon of the Killifish Nothobranchius furzeri.

Aug 26, 2021

The aging central nervous system (CNS) of mammals displays progressive limited regenerative abilities. Recovery after loss of neurons is extremely restricted in the aged brain. Many research models fa...

Cannabidiol reduces lesion volume and restores vestibulomotor and cognitive function following moderately severe traumatic brain injury.

Aug 26, 2021

Despite the high incidence of traumatic brain injury (TBI), there is no universal treatment to safely treat patients. Blunt brain injuries destroy primary neural tissue that results in impaired perfus...

Exploring the outcomes and experiences of Black and White athletes following a sport-related concussion: a retrospective cohort study.

Aug 26, 2021

Young American athletes, at risk of sport-related concussion (SRC), represent many races; however, it is unknown how race may influence the experience and outcome of SRC. The authors' objective was to...

Treatment Persistence of Renin-Angiotensin-Aldosterone-System Inhibitors over Time in Heart Failure with Reduced Ejection Fraction.

Aug 26, 2021

Clinical practice guidelines support sustained use of renin-angiotensin-aldosterone-system (RAAS) inhibitors over time in heart failure with reduced ejection fraction, yet few data are available regar...

Sleep Outcomes From AWAKE-HF: A Randomized Clinical Trial of Sacubitril/Valsartan Versus Enalapril in Patients With Heart Failure With Reduced Ejection Fraction.

Aug 26, 2021

Heart failure and sleep disordered breathing have been increasingly recognized as co-occurring conditions. Their bidirectional relationship warrants investigation into whether heart failure therapy im...

Understanding patients' perceived health after critical illness: analysis of two prospective, longitudinal studies of ARDS survivors.

Aug 26, 2021

Perceived health is one of the strongest determinants of subjective well-being, but it has received little attention among survivors of acute respiratory distress syndrome (ARDS).How well do self-repo...

Venous Thromboembolism Prophylaxis in Critically Ill Adults - A Systematic Review and Network Meta-Analysis.

Aug 26, 2021

Critically ill adults are at increased risk of venous thromboembolism (VTE), including deep venous thrombosis (DVT), and pulmonary embolism (PE). Various agents exist for venous thromboprophylaxis in ...

Neuromuscular Electric Stimulation in Addition to Exercise Therapy in Patients with Lower Extremity Paresis Due to Acute Ischemic Stroke.

Aug 23, 2021

Exercise therapy and neuromuscular electrical stimulation (NMES) during the initial 14 days after stroke may benefit recovery of gait. We aimed to determine whether poststroke NMES of vastus medial an...

Protective effects of anti-HMGB1 monoclonal antibody on lung ischemia reperfusion injury in mice.

Aug 23, 2021

During ischemia reperfusion (IR) injury, high mobility group box 1 (HMGB1), a chromatin binding protein, is released from necrotic cells and triggers inflammatory responses. We assessed the therapeuti...

Out-of-hospital sepsis recognition by paramedics improves the course of disease and mortality: A single center retrospective study.

Aug 23, 2021

Early recognition of sepsis and a prompt initiation of goal-directed therapy is important for sepsis survival. Little is known about the impact of early recognition of sepsis in the out-of-hospital se...

A rare case of pulmonary nocardiosis comorbid with Sjogren's syndrome.

Aug 23, 2021

Nocardia is an opportunistic pathogen, which occurs in patients with autoimmune diseases and immune dysfunction, and can cause bacteremia and other life-threatening complications. The clinical manifes...

Secondary infections after diagnosis of severe radiation pneumonitis (SRP) among non-small cell lung cancer patients: pathogen distributions, choice of empirical antibiotics and the value of empirical antifungal treatment.

Aug 23, 2021

To assess pathogen distributions and antimicrobial sensitivity characteristics in non-small cell lung cancer (NSCLC) patients diagnosed with severe radiation pneumonitis with secondary infections.Data...

Monocyte human leukocyte antigen-DR but not β-D-glucan may help early diagnosing invasive Candida infection in critically ill patients.

Aug 23, 2021

Precision medicine risk stratification is desperately needed to both avoid systemic antifungals treatment delay and over prescription in the critically ill with risk factors. The aim of the present st...

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