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Critical Care General

Phase I Trial of Definitive Concurrent Chemoradiotherapy and Trametinib for KRAS-Mutated Non-Small Cell Lung Cancer.

Jan 24, 2022

This phase I trial (NCT01912625) evaluated the safety and pharmacokinetics of definitive concurrent chemoradiotherapy (cCRT) and the radiosensitizer trametinib (MEK1/2 inhibitor) for KRAS-mutated nonm...

The effectiveness of branching simulations in improving nurses' knowledge, attitudes, practice, and decision-making related to sepsis assessment and management.

Jan 24, 2022

Nurses have a key role in the early assessment and management of sepsis, which is crucial for optimal quality of care and better patient outcomes. However, sepsis in critical care patients is underrec...

[Acute cerebral circulation impairment associated with percutaneous coronary intervention].

Jan 24, 2022

The article deals with generalized literature data on the current importance of the problem concerning acute cerebral ischemia occurring during percutaneous coronary interventions. Pathophysiological ...

Risk factors of postoperative complications following total knee arthroplasty in Korea: A nationwide retrospective cohort study.

Jan 24, 2022

The number of patients undergoing total knee arthroplasty (TKA) is gradually increasing and there is also increase in postoperative complications. The patient's demographic, socio-economic factors, ho...

A Scoping Review of Cognitive Assessment in Adults With Acute Traumatic Brain Injury.

Jan 24, 2022

The purpose of this study was to describe and synthesize the current research regarding the prevailing cognitive domains impacted by acute traumatic brain injury (TBI) in adults. Standardized and nons...

Application of Second-Order Growth Mixture Modeling (SO-GMM) to Longitudinal TBI Outcome Research: 15-year Trajectories of Life Satisfaction in Adolescents and Young Adults (AYA) as an Example.

Jan 24, 2022

To demonstrate the application of Second-Order Growth Mixture Modeling using life satisfaction among adolescents and young adults with TBI up to 15 years post-injury.SO-GMM, a data-driven modeling app...

2-Benzyllawsone protects against polymicrobial sepsis and vascular hyporeactivity in swiss albino mice.

Jan 17, 2022

Novel naphthoquinone, 2-benzyllawsone (LT-9) was evaluated against vascular hyporeactivity and sepsis in cecal ligation and puncture (CLP) model in mice in view of its preliminary antibacterial and an...

Preseason Symptom Reporting and Cognition in Middle School Athletes with Past Concussions.

Jan 17, 2022

This study examined the association between past concussions and current preseason symptom reporting and cognitive performance in 9,257 youth ages 11-13. Participants completed neurocognitive testing ...

Total body irradiation plus fludarabine versus thiotepa, busulfan plus fludarabine as a myeloablative conditioning for adults with acute lymphoblastic leukemia treated with haploidentical hematopoietic cell transplantation. A study by the Acute Leukemia Working Party of the EBMT.

Jan 17, 2022

Optimal conditioning for adults with acute lymphoblastic leukemia (ALL) treated with haploidentical hematopoietic cell transplantation (haplo-HCT) and post-transplant cyclophosphamide has not been est...

Myofibril orientation as a metric for characterizing heart disease.

Jan 17, 2022

Myocyte disarray is a hallmark of many cardiac disorders. However, the relationship between alterations in the orientation of individual myofibrils and myofilaments to disease progression has been lar...

Analysis of stroke care among 2019-2020 national emergency medical services information system encounters.

Jan 10, 2022

Emergency Medicine Service (EMS) providers play a pivotal role in early identification and initiation of treatment for stroke. The objective of this study is to characterize nationwide EMS practices f...

Autotransfusion of vaginally shed blood as a novel therapy in obstetric hemorrhage: A case series.

Jan 10, 2022

To report maternal outcomes in a cohort of women who received autotransfusion of vaginally shed blood and to describe the feasibility of blood collection and cell salvage processing at the time of vag...

Antithrombotic Therapy After Percutaneous Coronary Intervention in Patients With Atrial Fibrillation: Findings From the CONNECT AF+PCI Study.

Jan 10, 2022

In patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI), selecting an antithrombotic regimen requires balancing risks of ischemic cardiac events, stroke, and blee...

Economic Effects of Occupational Therapy Services for Adults in Acute and Subacute Care Settings: A Systematic Review.

Jan 10, 2022

Research supports the clinical effectiveness of hospital-based occupational therapy to improve functional outcomes, but no synthesis of economic evaluations of occupational therapy services provided i...

Takotsubo cardiomyopathy in post-traumatic brain injury: A systematic review of diagnosis and management.

Jan 10, 2022

Myocardial dysfunction is a known complication in patients who experience severe stressful events, such as traumatic brain injuries (TBI). One common manifestation is Takotsubo Cardiomyopathy (TC) whi...

Risks of Cardiovascular Events in Patients with Inflammatory Bowel Disease in China: A Retrospective Multicenter Cohort Study.

Jan 03, 2022

Inflammatory bowel disease (IBD) is a complex chronic disorder characterized by systemic inflammation, which may cause abnormal state of coagulation, resulting in cardiac events. This study aimed to i...

Molecular Diagnosis of Pneumonia (Including Multiplex Panels).

Jan 03, 2022

Pneumonia is a common illness, accounting for a staggering amount of worldwide morbidity and mortality. The diagnosis of pneumonia is challenging given the variety of responsible pathogens. Diagnostic...

Isolation and characterization of Staphylococcus argenteus strains from retail foods and slaughterhouses in Japan.

Jan 03, 2022

Staphylococcus argenteus has been recently established as a novel species of Staphylococcus aureus complex. It is known to cause various human diseases, such as skin and soft-tissue infections, sepsis...

Flomoxef for neonates: extending options for treatment of neonatal sepsis caused by ESBL-producing Enterobacterales.

Jan 03, 2022

Neonatal sepsis is a serious and frequently lethal infection, often complicated by antimicrobial resistance (including ESBLs) in low- and middle-income countries (LMICs). Flomoxef is an off-patent oxa...

An intervention to improve knowledge and increase comfort of concussion management among school medical staff.

Jan 03, 2022

Concussion can negatively impact a child's ability to learn. School-based health professional staff have a unique opportunity to monitor students during recovery and mitigate the potential negative im...

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