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Critical Care General

Identification of conditionally essential genes for infection in pigs.

May 19, 2020

is a Gram-positive bacterium and zoonotic pathogen that causes meningitis and sepsis in pigs and humans. The aim of this study was to identify genes required for infection. We created Tn-Seq librari...

Sepsis and ECMO.

May 19, 2020

Sepsis is being recognized as an important complication of extracorporeal membrane oxygenation (ECMO) and its presence is a poor prognostic marker and increases the overall mortality. The survival rat...

Outer Membrane Protein, Oma87 Prevents Infection.

May 19, 2020

is one of the most problematic pathogens in clinical settings. Emerging of its antibiotic-resistant strains persuade researchers to find alternative treatment options such as immunization against the...

Monophosphoryl lipid A pretreatment suppresses sepsis- and LPS-induced proinflammatory cytokine production in medullary thick ascending limb.

May 19, 2020

Sepsis is the leading cause of acute kidney injury in critically ill patients. Tumor necrosis factor-α (TNF-α) is implicated in the pathogenesis of septic kidney injury; however, the sites and mecha...

Incidence and treatment costs of severe bacterial infections among people who inject heroin: A cohort study in South London, England.

May 19, 2020

People who inject drugs often get bacterial infections. Few longitudinal studies have reported the incidence and treatment costs of these infections.For a cohort of 2335 people who inject heroin enter...

Effectiveness of radiotherapy to prevent recurrence of heterotopic ossification in patients with spinal cord injury and traumatic head injury: A retrospective case-controlled study.

May 19, 2020

To evaluate recurrence and early postoperative complications (sepsis) following surgical excision combined with radiotherapy for troublesome hip heterotopic ossification in patients with spinal cord i...

Contextual sensory integration training via head mounted display for individuals with vestibular disorders: a feasibility study.

May 19, 2020

Virtual reality (VR) interventions can simulate real-world sensory environments. The purpose of this study was to test the feasibility of a novel VR application (app) developed for a Head Mounted Dis...

Prognosis and futility in neurosurgical emergencies: A review.

May 19, 2020

A patient with a life-threatening intracranial insult presents a difficult situation to the neurosurgeon. In a few short minutes the neurosurgeon must assess the patient's neurologic status, imaging, ...

Incidence of and risk factors for late cholecystectomy in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.

May 19, 2020

Gallbladder disease and need for cholecystectomy are common and significant contributors to patient morbidity and healthcare costs. Childhood cancer survivors are at elevated risk for developing chole...

Improving Discourse following Traumatic Brain Injury: A Tale of Two Treatments.

May 19, 2020

Persons with traumatic brain injury (TBI) often present with discourse-level deficits that affect functional communication. These deficits are not thought to be primarily linguistic in nature but inst...

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure.

May 19, 2020

In response to an injury, such as myocardial infarction, prolonged hypertension or a cardiotoxic agent, the heart initially adapts through the activation of signal transduction pathways, to counteract...

The Development and Implementation of a Cardiac Home Hospice Program: Results of a RE-AIM Analysis.

May 19, 2020

Use of hospice has grown among patients with heart failure; however, gaps remain in the ability of agencies to tailor services to meet their needs.This study describes the implementation of a cardiac ...

Levosimendan reduces segmental pulmonary vascular resistance in isolated perfused rat lungs and relaxes human pulmonary vessels.

May 19, 2020

Levosimendan is approved for acute heart failure. Within this context, pulmonary hypertension represents a frequent co-morbidity. Hence, the effects of levosimendan on segmental pulmonary vascular res...

Prognostic value of plasma mitochondrial DNA in acute respiratory distress syndrome (ARDS): a single-center observational study.

May 19, 2020

Mitochondrial DNA (mtDNA) has been reported to play a critical role in the progression of systemic inflammatory response syndrome (SIRS). The pathophysiology of acute respiratory distress syndrome (AR...

Up-regulated CCL2 promotes ischemic stroke via chemokine signaling pathway.

May 19, 2020

This study aims to evaluate the potential effect and the underlying mechanism of CCL2 in ischemic stroke.An integrated bioinformatics analysis was performed to identify the differentially expressed (D...

An Updated Systematic Review and Meta-Analysis of Results of Transcervical Carotid Artery Stenting with Flow Reversal.

May 19, 2020

Transcervical carotid artery stenting (CAS) has emerged as an alternative to transfemoral CAS. An earlier systematic review from our group (n = 12 studies; 739 transcervical CAS procedures [489/739 wi...

Isovaleroylbinankadsurin A ameliorates cardiac ischemia/reperfusion injury through activating GR dependent RISK signaling.

May 19, 2020

Ischemia/reperfusion (I/R) injury is a pathological process caused by reperfusion. The prevention of I/R injury is of great importance as it would enhance the efficacy of myocardial infarction treatme...

A directed network analysis of the cardiome identifies molecular pathways contributing to the development of HFpEF.

May 19, 2020

The metabolic syndrome and associated comorbidities, like diabetes, hypertension and obesity, have been implicated in the development of heart failure with preserved ejection fraction (HFpEF). The mol...

Demographic Characteristics Among Patients With Chronic Exertional Compartment Syndrome of the Lower Leg.

May 19, 2020

Clinical Scenario: Chronic exertional compartment syndrome (CECS) is a condition related with ischemia of the body's tissue due to increases in intracompartmental pressures, which involves, among othe...

Severe obesity is associated with higher in-hospital mortality in a cohort of patients with COVID-19 in the Bronx, New York.

May 19, 2020

New York is the current epicenter of Coronavirus disease 2019 (COVID-19) pandemic. The underrepresented minorities, where the prevalence of obesity is higher, appear to be affected disproportionately....

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