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Critical Care General

Innovative Left Ventricular Assist Device in High-fidelity Patient Simulator.

May 28, 2020

Left ventricular assist devices (LVADs) are implantable mechanical devices that pump blood from the apex of the left ventricle to the aorta in order to assist the forward flow of blood; they are most ...

Characteristics of Effective Teachers of Invasive Bedside Procedures: A Multi-Institutional Qualitative Study.

May 28, 2020

Faculty supervision of invasive bedside procedures (IBPs) in the intensive care unit (ICU) may enhance procedural education and ensure patient safety. However, there is limited research on teaching ef...

Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA).

May 28, 2020

Intravenous fluid administration should be considered as any other pharmacological prescription. There are three main indications: resuscitation, replacement, and maintenance. Moreover, the impact of ...

Platelets in Thrombo-Inflammation: Concepts, Mechanisms, and Therapeutic Strategies for Ischemic Stroke.

May 28, 2020

Platelets are anucleate cells known for their essential function in hemostasis and formation of thrombi under pathologic conditions. In recent years, strong evidence emerged demonstrating the critical...

[Clinical feature changes of a COVID-19 patient from mild to critical condition and cardiopulmonary pathological results].

May 28, 2020

To analyse the clinical history, laboratory tests and pathological data of a patient who suffered from novel coronavirus pneumonia(COVID-19) and provide reference for the clinical treatment of simila...

Effect of Serum Netrin-1 Levels on Diagnosis and Prognosis in Patients Admitted to the Emergency Service for Acute Coronary Syndrome.

May 28, 2020

Background Netrin-1 is a recently discovered diagnostic biomarker that indicates atherosclerosis, angiogenesis, and ischemia-reperfusion damage. There are no human studies about Netrin-1 in acute coro...

En Bloc Celiac Axis Resection for Pancreatic Cancer: Classification of Anatomical Variants Based on Tumor Extent.

May 19, 2020

En bloc celiac axis resection (CAR) for pancreatic cancer (PC) is increasingly considered after modern neoadjuvant chemotherapy (NAC). "Appleby" and "DP-CAR" are anatomically inaccurate terms as tumor...

Interleukin-36β activates autophagy of CD4+CD25+ regulatory T cells and inhibits its immunosuppressive activity in sepsis.

May 19, 2020

CD4+CD25+ regulatory T cells (Tregs) play an essential role in sepsis-induced immunosuppression. How, the effects of interleukin (IL)-36 cytokines on CD4+CD25+ Tregs and their underlying mechanism(s) ...

Systematic Review: Models of Changes in Gene Expression of MTOR, MURF-1, and MAFBX in Rats and Mice.

May 19, 2020

Various pathologies and lifestyle factors, such as nutritional factors and physical exercises, can alter the gene expression of proteins related to synthesis and degradation.We performed a systematic ...

Estimated plasma volume status (ePVS) could be an easy-to-use clinical tool to determine the risk of sepsis or death in patients with fever.

May 19, 2020

Capillary permeability can be increased in patients with sepsis. Indirect estimation of plasma volume status (ePVS) could identify more severely ill patients with fever.1502 patients evaluated for fev...

Selective inhibition of interleukin-1 receptor-associated kinase 1 ameliorates lipopolysaccharide-induced sepsis in mice.

May 19, 2020

Interleukin-1 receptor-associated kinases (IRAKs), particularly IRAK1 and IRAK4, are important in transducing signal from Toll-like receptor 4. We interrogated if a selective inhibition of IRAK1 could...

Plasma pharmacokinetics of ceftolozane/tazobactam in pediatric patients with cystic fibrosis.

May 19, 2020

The antipseudomonal cephalosporin/β-lactamase inhibitor combination ceftolozane/tazobactam could be a potential treatment option for cystic fibrosis (CF) pulmonary exacerbations. The pharmacokinetics...

Effects of SARS-CoV-2 infection on pregnant women and their infants: A retrospective study in Wuhan, China.

May 19, 2020

The pandemic of a novel coronavirus, termed SARS-CoV-2, has created an unprecedented global health burden. To investigate the effect of the SARS-CoV-2 infection on maternal, fetal, and neonatal morb...

Autopsy Report with Clinical Pathological Correlation.

May 19, 2020

Since making its debut on the global stage in December 2019, Coronavirus Disease 2019 (COVID-19) has afflicted nearly four million people and caused hundreds of thousands of deaths. Case reports and c...

Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy.

May 19, 2020

In December, 2019, reports emerged from Wuhan, China, of a severe acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). By the end of April, 2020, over 3 mi...

Investigation of a COVID-19 outbreak in Germany resulting from a single travel-associated primary case: a case series.

May 19, 2020

In December, 2019, the newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, causing COVID-19, a respiratory disease presenting with fever, cough, and ...

Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

May 19, 2020

Angiotensin-converting enzyme-2 (ACE2) may increase due to upregulation in patients using angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB). Because renin-angiote...

The study of transcarotid artery revascularization under local versus general anesthesia with results from the Society for Vascular Surgery Vascular Quality Initiative.

May 19, 2020

The primary purpose of this study was to examine any potential difference in clinical outcomes between transcarotid artery revascularization performed under local anesthesia compared with general anes...

Caffeinated Beverage Intake, Dyspnea With Ticagrelor, and Cardiovascular Outcomes: Insights From the PEGASUS-TIMI 54 Trial.

May 19, 2020

Background A proposed cause of dyspnea induced by ticagrelor is an increase in adenosine blood levels. Because caffeine is an adenosine antagonist, it can potentially improve drug tolerability with re...

Melatonin Ameliorates MI-Induced Cardiac Remodeling and Apoptosis through a JNK/p53-Dependent Mechanism in Diabetes Mellitus.

May 19, 2020

Diabetes mellitus, a worldwide health threat, is considered an independent risk factor for cardiovascular diseases. The overall cardiovascular risk of diabetes is similar to the one having one myocard...

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