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Critical Care General

Motor Deficits in Youth with Concussion History: Issues with Task Novelty or Task Demand?

Jun 04, 2020

The present study expands previous work on eye-hand decoupling deficits in youth with concussion history. It examines whether deficits can be linked to difficulties adapting to new task constraints or...

Analysis of extracellular vesicle miRNA profiles in heart failure.

Jun 04, 2020

Extracellular vesicles (EVs) have recently emerged as an important carrier for various genetic materials including microRNAs (miRs). Growing evidences suggested that several miRs transported by EVs we...

A novel risk score for predicting left atrial and left atrial appendage thrombogenic milieu in patients with non-valvular atrial fibrillation.

Jun 04, 2020

Although the CHADS2 and CHA2DS2-VASc scoring systems are commonly used as measures of thromboembolic risk in patients with nonvalvular atrial fibrillation (NVAF), data are inconsistent as to their val...

Elevated level of cerebrospinal fluid and systemic chemokine CCL5 is a predictive biomarker of clinical outcome after aneurysmal subarachnoid hemorrhage (aSAH).

Jun 04, 2020

Pathophysiology of aneurysmal subarachnoid hemorrhage (aSAH) is highly complex. Bleeding from ruptured aneurysm causes increase in intracranial pressure that disrupts blood-brain barrier leading to in...

Stem cell mobilization with plerixafor and healing of diabetic ischemic wounds: A phase IIa, randomized, double-blind, placebo-controlled trial.

Jun 04, 2020

Bone marrow-derived cells contribute to tissue repair, but traffic of hematopoietic stem/progenitor cells (HSPCs) is impaired in diabetes. We therefore tested whether HSPC mobilization with the CXCR4 ...

Risk of incident bleeding after acute kidney injury: A retrospective cohort study.

Jun 04, 2020

End-stage kidney disease (ESKD) causes bleeding diathesis; however, whether these findings are extrapolable to acute kidney injury (AKI) remains uncertain. We assessed whether AKI is associated with a...

Cardiovascular (CV) Benefit of Empagliflozin Across the Spectrum of CV Risk Factor Control in the EMPA-REG OUTCOME Trial.

Jun 04, 2020

Control of multiple cardiovascular (CV) risk factors reduces CV events in individuals with type 2 diabetes (T2D).To investigate this association in a contemporary clinical trial population, including ...

Baicalin combats glutamate excitotoxicity via protecting glutamine synthetase from ROS-induced 20S proteasomal degradation.

Jun 01, 2020

Many neuroprotective approaches targeting neurons in animal models fail to provide benefits for the treatment of ischemic stroke in clinic and glial cells have become the targets in some basic studies...

Nitrate migration and transformations in groundwater quantified by dual nitrate isotopes and hydrochemistry in a karst World Heritage site.

Jun 01, 2020

Karst aquifers are extremely vulnerable to pollution, including from nitrate. This research advances a systematic evaluation of water quality dynamics and processes in a relatively pristine karst flow...

Clinical investigation of the utility of a pair of coagulation-fibrinolysis markers for definite diagnosis of sepsis-induced disseminated intravascular coagulation: A single-center, diagnostic, prospective, observational study.

Jun 01, 2020

Disseminated intravascular coagulation (DIC) often occurs with sepsis. A scoring system has been used for the diagnosis of DIC, but the system included at least 4 parameters. The purpose of this study...

Recombinant human ulinastatin improves immune dysfunction of dendritic cells in septic mice by inhibiting endoplasmic reticulum stress-related apoptosis.

Jun 01, 2020

Urinary trypsin inhibitor (UTI), also known as ulinastatin, has been reported to protect multiple organs against inflammation- and/or injury-induced dysfunction. In the present study, we aimed to inve...

Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients.

Jun 01, 2020

Baricitinib, is an oral Janus kinase (JAK)1/JAK2 inhibitor approved for the treatment of rheumatoid arthritis (RA) that was independently predicted, using artificial intelligence (AI)-algorithms, to b...

Acute respiratory failure among lung transplant adults requiring intensive care: Changing spectrum of causative organisms and impact of procalcitonin test in the diagnostic work up.

Jun 01, 2020

The aim was to identify the causing organisms and assess the association of procalcitonin (PCT) with bacterial pneumonia within 24-hours of intensive care unit admission (ICU-A) among lung transplant ...

miR-532-3p-CSF2RA Axis as a Key Regulator of Vulnerable Atherosclerotic Plaque Formation.

Jun 01, 2020

The most dangerous atherosclerotic plaques, referred to as "vulnerable," are most likely to trigger acute atherothrombotic events such as myocardial infarction (heart attack) and stroke. Our goal was ...

The effects of body mass index on outcomes for patients undergoing surgical aortic valve replacement.

Jun 01, 2020

Most of the studies of obesity and postoperative outcome have looked predominantly at coronary artery bypass grafting with fewer focused on valvular disease. The purpose of this study was to compare t...

Prognostic accuracy of SIRS criteria and qSOFA score for in-hospital mortality among influenza patients in the emergency department.

Jun 01, 2020

The seasonal influenza epidemic is an important public health issue worldwide. Early predictive identification of patients with potentially worse outcome is important in the emergency department (ED)....

Whole blood transcriptomic investigation identifies long non-coding RNAs as regulators in sepsis.

Jun 01, 2020

Sepsis is a fatal disease referring to the presence of a known or strongly suspected infection coupled with systemic and uncontrolled immune activation causing multiple organ failure. However, curren...

Effectiveness of the Brains Ahead! Intervention: 6 Months Results of a Randomized Controlled Trial in School-Aged Children With Mild Traumatic Brain Injury.

Jun 01, 2020

To examine the effectiveness of Brains Ahead!, a psychoeducational intervention aimed to prevent long-term problems with activities and participation in children after mild traumatic brain injury (mTB...

Activities and Participation in the First 6 Months After Mild Traumatic Brain Injury in Children and Adolescents.

Jun 01, 2020

To investigate the natural course of activities and participation of children up to 6 months after a mild traumatic brain injury (mTBI).A prospective longitudinal cohort study with complete data sets ...

How Repetitive Traumatic Injury Alters Long-Term Brain Function.

Jun 01, 2020

How recurrent traumatic brain injury (rTBI) alters brain function years after insult is largely unknown. This study aims to characterize the mechanistic cause for long-term brain deterioration followi...

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