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Critical Care General

The 5 and 11 Factor Modified Frailty Indices are Equally Effective at Outcome Prediction Using TQIP.

Jul 06, 2020

The 5-factor modified frailty index (mFI-5) and the 11-factor modified frailty index (mFI-11) are equally effective in predicting adverse outcomes in the American College of Surgeons National Surgical...

Automated stroke lesion segmentation in non-contrast CT scans using dense multi-path contextual generative adversarial network.

Jul 02, 2020

Stroke lesion volume is a key radiologic measurement in assessing prognosis of acute ischemic stroke (AIS) patients. The aim of this paper is to develop an automated segmentation method for accurately...

Trans-cranial Doppler predicts early neurologic deterioration in anterior circulation ischemic stroke after successful endovascular treatment.

Jul 02, 2020

Early neurologic deterioration (END) may occur in patients with anterior circulation ischemic stroke (ACIS) after receiving endovascular treatment (EVT). Hemodynamic insufficiency, re-occlusion, and p...

Diagnosing Calciphylaxis: A Review With Emphasis on Histopathology.

Jul 02, 2020

Calciphylaxis is a cutaneous vasculopathy with high morbidity and mortality characterized by vascular intimal fibrosis, calcification, stenosis, thrombosis, and eventual tissue death due to ischemia. ...

The Effect of Xinmailong Infusion on Sepsis-Induced Myocardial Dysfunction: A Pragmatic Randomized Controlled Trial.

Jul 02, 2020

Sepsis-induced myocardial dysfunction (SIMD) contributes significantly to cardiovascular dysfunction during septic shock. We aimed to evaluate the potential role of Xinmailong injection (XMLI), a poly...

Outcomes and Disposition of Oncology Patients With Non-neutropenic Fever and Positive Blood Cultures.

Jul 02, 2020

Children with cancer and non-neutropenic fever (NNF) episodes are often treated as outpatients if they appear well. However, a small subset have bloodstream infections (BSIs) and must return for furth...

Dose optimized chest CT for diagnosis of COVID-19 - Evaluation of the image quality and diagnostic impact.

Jul 02, 2020

The detection of COVID-19 by reverse transcription polymerase chain reaction (RT-PCR) has varying sensitivity. CT of the chest can verify the infection in patients with clinical symptoms and a negativ...

Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo'.

Jul 02, 2020

On the 21 of February 2020 a resident of the municipality of Vo', a small town near Padua, died of pneumonia due to SARS-CoV-2 infection. This was the first COVID-19 death detected in Italy since the ...

Iron imaging in myocardial infarction reperfusion injury.

Jul 02, 2020

Restoration of coronary blood flow after a heart attack can cause reperfusion injury potentially leading to impaired cardiac function, adverse tissue remodeling and heart failure. Iron is an essential...

External validation of the sepsis severity score.

Jul 02, 2020

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Mortality rates are high, exceeding 50% in patients with septic shock. The sepsis severit...

Elevated trefoil factor 3 plasma levels in critically ill patients with abdominal sepsis or non-infectious abdominal illness.

Jul 02, 2020

Trefoil factor 3 (TFF3) is a small peptide secreted mainly by goblet cells in the gut, where it plays a key role in gastrointestinal defence and repair. Plasma TFF3 has been reported as a biomarker of...

Therapeutic Potential of B-1a Cells in COVID-19.

Jul 02, 2020

Coronavirus disease 2019 (COVID-19) is a life-threatening respiratory illness caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its clinical presentation can vary from ...

Proteomic changes by radio-mitigative thrombopoietin receptor agonist Romiplostim in the blood of mice exposed to lethal total-body irradiation.

Jul 02, 2020

The thrombopoietin receptor agonist romiplostim (RP) is a therapeutic agent for immune thrombocytopenia that can achieve complete survival in mice exposed to a lethal dose of ionizing radiation. The ...

The relationship between neurovascular coupling, vision and sensory performance, and concussion history in Special Operations Forces combat soldiers.

Jul 02, 2020

To determine the relationship between neurovascular coupling (NVC), vision and sensory performance in Special Operations Forces (SOF) combat soldiers with and without concussion history. We studied 6...

Fatal accident involving a welder employed by a shipping container company, associated with the use of tramadol and antidepressant agents.

Jul 02, 2020

The widespread use of opioids for the treatment of moderate or severe acute and chronic pain has become a public health problem due to the physical and psychological dependence and tolerance they prod...

His Bundle and Left Bundle Pacing with Optimised Atrio-ventricular Delay Achieve Superior Electrical Synchrony over Endocardial and Epicardial Pacing in Left Bundle Branch Block Patients.

Jul 02, 2020

His bundle pacing (HBP) and left bundle pacing (LBP) are emerging as novel delivery methods for cardiac resynchronisation therapy (CRT) in heart failure patients with left bundle branch block (LBBB). ...

Digoxin Initiation and Outcomes in Patients with Heart Failure (HFrEF and HFpEF) and Atrial Fibrillation.

Jul 02, 2020

Digoxin reduces the risk of heart failure hospitalization but has no effect on mortality in patients with heart failure without atrial fibrillation in the randomized controlled trial setting. Observat...

Exercise Training Effects on the Relationship of Physical Function and Health-Related Quality of Life Among Older Heart Failure Patients With Preserved Ejection Fraction.

Jul 02, 2020

Although exercise training (ET) has been shown to improve both physical function and health-related quality of life (HRQOL) in older patients with heart failure and preserved ejection fraction (HFpEF)...

Phthalide derivative CD21 ameliorates ischemic brain injury in a mouse model of global cerebral ischemia: involvement of inhibition of NLRP3.

Jun 29, 2020

The activation of NLRP3 inflammasome is closely related to ischemic brain injury and inhibition of NLRP3 inflammasome activation may be a new therapeutic strategy for ischemic stroke. Our previous stu...

Probiotics Reduce Mortality and Morbidity in Preterm, Low Birth Weight Infants: a Systematic Review and Network Meta-analysis of Randomized Trials.

Jun 29, 2020

We aimed to compare the effectiveness of single- vs multiple-strain probiotics in a network meta-analysis of randomized trials.We searched MEDLINE, EMBASE, Science Citation Index Expanded, CINAHL, Sco...

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