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Critical Care General

Intensity of Renal Replacement Therapy and Duration of Mechanical Ventilation: Secondary Analysis of the Acute Renal Failure Trial Network Study.

Jul 16, 2020

Randomized clinical trials have failed to show benefit from increasing intensity of renal replacement therapy (RRT) but continue to be frequently used. In addition, intensive RRT is associated with an...

Using Causal Diagrams to Improve the Design and Interpretation of Medical Research.

Jul 16, 2020

Causal directed acyclic graphs (cDAGs) have become popular tools for researchers to better examine biases related to causal questions. DAGs comprise a series of arrows connecting nodes that represent ...

A Nitric Oxide-Releasing Hydrogel for Enhancing the Therapeutic Effects of Mesenchymal Stem Cell Therapy for Hindlimb Ischemia.

Jul 16, 2020

Therapeutic angiogenesis with mesenchymal stem cells (MSCs) is promising for the clinical treatment of peripheral artery disease (PAD). However, the heterogeneous proangiogenic nature of MSCs is a key...

The diagnoses and outcomes of emergency patients with an elevated D-dimer over the next 90 days.

Jul 16, 2020

it is not known what diagnoses are associated with an elevated D-dimer in unselected patients attending emergency departments (ED), nor their associated outcomes.prospective observational study of 1,6...

Rationale and design of the RIGHT trial: A multicenter, randomized, double-blind, placebo-controlled trial of anticoagulation prolongation versus no anticoagulation after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction.

Jul 16, 2020

Current guidelines recommend anticoagulation therapy during primary percutaneous coronary intervention (pPCI) for ST-segment elevation myocardial infarction (STEMI). However, whether anticoagulation s...

Conference Highlights - AIDS 2020: Virtual - A Focus on COVID-19

Jul 14, 2020

New research was presented at AIDS 2020: Virtual, the 23rd International AIDS Conference, from July 6-10, much of it focused on the intersection of COVID-19 and HIV. The features below highlight some ...

Long-term risk of heart failure and mortality following mitral valve surgery in patients with and without right ventricular pacemaker.

Jul 13, 2020

Patients undergoing mitral valve surgery are at risk of developing postoperative conduction blocks and have a high incidence of heart failure (HF). Mitral valve surgery often results in reduced left v...

Organ care system lung resulted in lower apoptosis and inos expression in donor lungs.

Jul 13, 2020

Ischemia/reperfusion injury after lung transplantation is still today an important complication in up to 25% of patients. The Organ Care System (OCS) Lung, an advanced normothermic ex-vivo lung perfus...

Use of perfusion index to detect hemodynamic changes in endotoxemic pigs.

Jul 13, 2020

The perfusion index (PI) derived from plethysmographic signals provides a noninvasive indication of peripheral perfusion. This study aimed to investigate changes in PI and other hemodynamic variables ...

Clinical characteristics and outcome of SARS-CoV-2 infection in Italian pediatric oncology patients: a study from the Infectious Diseases Working Group of the AIEOP.

Jul 13, 2020

Little is known as yet about the outcome of SARS-CoV-2 infection in children being treated for cancer.We collected information on the clinical characteristics and outcomes of a cohort of 29 children (...

Anxiety and Depression of Nurses in a North West Province in China During the Period of Novel Coronavirus Pneumonia Outbreak.

Jul 13, 2020

To investigate the anxiety and depression levels of frontline clinical nurses working in 14 hospitals in Gansu Province, China, during this period.A cross-sectional survey was conducted online between...

Dementia screening in elderly high-risk patients following heart failure decompensation may predict unfavorable long-term clinical outcomes.

Jul 13, 2020

Recently heart failure (HF) has been found to be a new dementia risk factor, nevertheless their relations in patients following HF decompensation remain unknown. We sought to investigate whether a scr...

Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo.

Jul 13, 2020

Mitochondrial reactive oxygen species (ROS) production upon reperfusion of ischemic tissue initiates the ischemia/reperfusion (I/R) injury associated with heart attack. During ischemia, succinate accu...

Clinical safety profile of transendocardial catheter injection systems: A plea for uniform reporting.

Jul 13, 2020

The aim of this study was to characterize the clinical safety profile of transendocardial injection catheters (TIC) reported in the published literature.Transendocardial delivery is a minimally invasi...

Monocytic human leukocyte antigen DR expression in young infants undergoing cardiopulmonary bypass.

Jul 13, 2020

Monocytic human leukocyte antigen DR (mHLA-DR) expression levels have been reported to be a marker of immunosuppression and a predictor of sepsis and mortality. There is, however, scant data regarding...

Cardiac Troponin for the Diagnosis and Risk-Stratification of Myocardial Injury in COVID-19: JACC Review Topic of the Week.

Jul 13, 2020

Increases in cardiac troponin (cTn) indicative of myocardial injury are common in patients with COVID-19 and associated with adverse outcomes such as arrhythmias and death. These increases are more li...

Thymopentin improves the survival of septic mice by promoting the production of 15-deoxy-prostaglandin J2 and activating the PPARγ signaling pathway.

Jul 13, 2020

Sepsis, a systemic inflammatory response syndrome (SIRS) caused by infection, is a major public health concern with limited therapeutic options. Infection disturbs the homeostasis of host, resulting i...

Soccer Heading and Subclinical Neuropsychiatric Symptomatology in Professional Soccer Players.

Jul 13, 2020

To evaluate the association between post-concussive symptomatology and heading in professional soccer players, overcoming the bias of self-reported exposure, we evaluated several clinical neuropsychia...

Targeting higher levels of lactate in the post-injury period following traumatic brain injury.

Jul 13, 2020

Secondary traumatic brain injury (TBI) consequences continue multiple cascades of biochemical reactions caused by initial neurotrauma and one of the important pathogenetic processes is mitochondrial d...

Controlling nutritional status (CONUT) score is a predictive marker for patients with traumatic brain injury.

Jul 13, 2020

We designed this study to evaluate whether controlling nutritional status (CONUT) score was valuable in predicting outcome of patients with traumatic brain injury (TBI).Clinical and laboratory data of...

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