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Critical Care General

[Dynamics of Parameters of Transmitral Blood Flow and Markers of Myocardial Fibrosis in Patients with Myocardial Infarction].

Jul 30, 2020

Aim      To study possible correlations between echocardiography (EchoCG) indexes and markers of myocardial fibrosis, procollagen I C-terminal propeptide (PICP) and procollagen III N-terminal pro...

Sleep quality and ventilatory efficiency in elderly heart failure patients: a pilot study on the short-term effect of 4-week low-intensity aerobic exercise.

Jul 30, 2020

Background Sleep disturbance and ventilator inefficiency are considered two of the most critical complications for general human wellbeing, particularly in elderly heart failure (HF) patients. Studies...

Mechanical thrombectomy using the new Tigertriever in acute ischemic stroke patients - A Swiss prospective multicenter study.

Jul 30, 2020

Tigertriever is a novel operator-adjustable clot retriever designed to enhance the operator's options to control the interaction of retriever and clot. The aim of this study was to assess the feasibil...

Off-Label Dosing of Non-Vitamin K Antagonist Oral Anticoagulants and Clinical Outcomes in Asian Patients with Atrial Fibrillation.

Jul 27, 2020

Prescriptions of off-label dosing non-vitamin K antagonist oral anticoagulants (NOACs) are common for Asian patients with atrial fibrillation (AF).To investigate the associations between inappropriate...

Pro-atrial natriuretic peptide and pro-adrenomedullin before cardiac surgery in children. Can we predict the future?

Jul 27, 2020

Pro-atrial natriuretic peptide (proANP) and pro-adrenomedullin (proADM) levels increase in acute heart failure and sepsis. After cardiac surgery, children may require increased support in the intensiv...

The autocrine regulation of Interleukin-3 on the activity of regulatory T cells and its effectiveness in the pathophysiology of sepsis.

Jul 27, 2020

Tregs play a crucial role in modulating the inflammatory response and participated in the sepsis-related immune dysfunctions. However, little is known about the regulatory mechanisms by which Tregs ar...

Embelin ameliorated sepsis-induced disseminated intravascular coagulation intensities by simultaneously suppressing inflammation and thrombosis.

Jul 27, 2020

Disseminated intravascular coagulation (DIC), an acute syndrome of systemic thrombus formation in microvasculatures throughout the body, can be induced by severe infections, e.g. sepsis. Anticoagulant...

Ex vivo synthesized cytokines as a biomarker of stroke-associated pneumonia.

Jul 27, 2020

We aimed to determine a profile of ex vivo released cytokines in patients with stroke-associated pneumonia (SAP) and to assess the clinical utility of individual cytokines and their combination as a b...

Care complexity individual factors associated with adverse events and in-hospital mortality.

Jul 27, 2020

Measuring the impact of care complexity on health outcomes, based on psychosocial, biological and environmental circumstances, is important in order to detect predictors of early deterioration of inpa...

Comparison between esomeprazole 20 mg Vs 40 mg as stress ulcer prophylaxis (SUP) in critically ill patients: A retrospective cohort study.

Jul 27, 2020

Critically ill patients admitted to intensive care units (ICUs) are at high risk of developing upper gastrointestinal bleeding due to GI stress ulceration (SU). The major independent risk factors for ...

The role and function of IκKα/β in monocyte impairment.

Jul 27, 2020

Following major trauma, sepsis or surgery, some patients exhibit an impaired monocyte inflammatory response that is characterized by a decreased response to a subsequent bacterial challenge. To invest...

The Role of FER rs4957796 in the Risk of Developing and Dying from a Bloodstream Infection: A 23-Year Follow-up of the Population-based Nord-Trøndelag Health Study.

Jul 27, 2020

Bloodstream infection and sepsis are major causes of health loss worldwide, and it is important to identify patients at risk of developing and dying from these conditions. The single-nucleotide polymo...

Probability of sepsis after infection consultations in primary care in the United Kingdom in 2002-2017: Population-based cohort study and decision analytic model.

Jul 27, 2020

Efforts to reduce unnecessary antibiotic prescribing have coincided with increasing awareness of sepsis. We aimed to estimate the probability of sepsis following infection consultations in primary car...

Clinical characteristics and outcomes in patients with traumatic brain injury in China: a prospective, multicentre, longitudinal, observational study.

Jul 27, 2020

Large-scale studies are required to better characterise traumatic brain injury (TBI) and to identify the most effective treatment approaches for TBI. However, evidence is scarce and mostly originates ...

Effect of Cognitive and Physical Rest on Persistent Post-Concussive Symptoms Following a Pediatric Head Injury.

Jul 27, 2020

To evaluate the effect of cognitive and physical rest on persistent post-concussive symptoms (PPCS) in a pediatric population.A prospective cohort study of 5-18-year-olds diagnosed with an acute concu...

Lasting consequences of concussion on the aging brain: findings from the Baltimore Longitudinal Study of Aging.

Jul 27, 2020

Studies suggest that concussions may be related to increased risk of neurodegenerative diseases, such as Chronic Traumatic Encephalopathy and Alzheimer's Disease. Most neuroimaging studies show effect...

Clinical Scenario and Long-term Outcome of Childhood Takayasu Arteritis Undergoing 121 Endovascular Interventions: The Largest Cohort over a 15-year Period.

Jul 27, 2020

Evidence-based studies on endovascular approaches for childhood Takayasu arteritis(c-TA) are limited. This study presents the largest real-world scenario up-to-date for c-TA patients undergoing interv...

Population Pharmacokinetics of Candesartan in Patients with Chronic Heart Failure.

Jul 27, 2020

Heart failure (HF) causes pathological changes in multiple organs, thus affecting the pharmacokinetics of drugs. The aim of this study was to investigate the pharmacokinetics of candesartan in HF pati...

Management and prevention of anemia (acute bleeding excluded) in adult critical care patients.

Jul 27, 2020

Anemia is very common in critical care patients, on admission (affecting about two-thirds of patients), but also during and after their stay, due to repeated blood loss, the effects of inflammation on...

Association of baseline kidney disease with outcomes of transcatheter mitral valve repair by MitraClip.

Jul 27, 2020

This study sought to determine the impact of baseline chronic kidney disease (CKD) on in-hospital outcomes of transcatheter mitral valve repair with MitraClip (MC).MC is now an established treatment i...

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