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Critical Care General

Multiple Opportunistic Infections Related to Hypercortisolemia due to Adrenocortical Carcinoma: A Case Report.

Sep 03, 2020

Cushing's syndrome is characterized by excessive cortisol and immuno-suppression. We experienced a case of Cushing's syndrome caused by adrenocortical carcinoma that was complicated by multiple opport...

Indications and complications of pelvic lymph node dissection for prostate cancer: are currently available nomograms accurate to predict lymph node invasion?

Sep 03, 2020

to externally validate currently available nomograms for predicting lymph node invasion (LNI) in prostate cancer (PCa) patients and to assess the potential risk of complications of extended pelvic lym...

Effect of Intraoperative Low Tidal Volume vs Conventional Tidal Volume on Postoperative Pulmonary Complications in Patients Undergoing Major Surgery: A Randomized Clinical Trial.

Sep 03, 2020

In patients who undergo mechanical ventilation during surgery, the ideal tidal volume is unclear.To determine whether low-tidal-volume ventilation compared with conventional ventilation during major s...

[Effect of electroacupuncture on neuronal apoptosis in rats with traumatic brain injury based on PI3K/Akt signaling pathway].

Sep 03, 2020

To observe the effect of electroacupuncture (EA) on neuronal apoptosis in rats with traumatic brain injury (TBI), and to explore the action mechanism of EA on improving the brain nerve function of TBI...

Traumatic brain injury substantially reduces the conditioned reinforcing effects of environmental cues in rats.

Sep 03, 2020

Traumatic brain injury affects millions of people each year and is an established risk factor for addiction. Recent animal studies have causally demonstrated that injuries can increase drug self-admin...

Mode and Intensity of Physical Activity During the Postacute Phase of Sport-Related Concussion: A Systematic Review.

Sep 03, 2020

Sports-related concussions (SRCs) have received attention due to their prevalence in youth. An SRC results from a strong force causing neurological impairment. Recent research has recommended rehabili...

Modelling genetic diseases for drug development: Hypertrophic cardiomyopathy.

Sep 03, 2020

Hypertrophic cardiomyopathy (HCM) is the commonest genetic cardiac disease, with a prevalence of 1/500. It is caused by over 1400 different mutations, mainly involving the genes coding for sarcomere p...

Congestion and nutrition as determinants of bioelectrical phase angle in heart failure.

Sep 03, 2020

The whole-body bioelectrical phase-angle (PhA) is emerging as a new tool in stratifying prognosis in patients with both acute (AHF) and chronic heart failure (CHF).To evaluate the determinants of PhA ...

Cerebral Collaterals In Acute Ischemia: Implications For Acute Ischemic Stroke Patients Receiving Reperfusion Therapy.

Sep 03, 2020

The cerebral collaterals play an important role in penumbral tissue sustenance after an acute ischemic stroke. Recent studies have demonstrated the potential role of collaterals in the selection of ac...

Chronic kidney disease and acute kidney injury in the COVID-19 Spanish outbreak.

Sep 03, 2020

Novel coronavirus disease 2019 (COVID-19) emerged in Wuhan and rapidly spread, affecting >10 million cases worldwide. Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and prim...

Rationale and design of the MULTISTARS AMI Trial: A randomized comparison of immediate versus staged complete revascularization in patients with ST-segment elevation myocardial infarction and multivessel disease.

Sep 03, 2020

About half of patients with acute ST-segment elevation myocardial infarction (STEMI) present with multivessel coronary artery disease (MVD). Recent evidence supports complete revascularization in thes...

Citicoline for treating people with acute ischemic stroke.

Aug 31, 2020

Stroke is one of the leading causes of long-lasting disability and mortality and its global burden has increased in the past two decades. Several therapies have been proposed for the recovery from, an...

The role of KCC2 in hyperexcitability of the neonatal brain.

Aug 31, 2020

The hyperpolarizing activity of γ-aminobutyric acid A (GABA) receptors depends on the intracellular chloride gradient that is developmentally regulated by the activity of the chloride extruder potass...

Nanotechnological strategies for systemic microbial infections treatment: A review.

Aug 31, 2020

Systemic infections is one of the major causes of mortality worldwide, and a shortage of drug approaches applied for the rapid and necessary treatment contribute to increase the levels of death in aff...

The Current Evidence for the Treatment of Sepsis with Xuebijing Injection: Bioactive Constituents, Findings of Clinical Studies and Potential Mechanisms.

Aug 31, 2020

Xuebijing (XBJ) injection is a Chinese medicine containing extracts from Carthamus tinctorius L. (Carthami Flos, hong hua, Asteraceae), Paeonia lactiflora Pall. (Paeoniae radix rubra, chi shao, Ranunc...

Tocilizumab use in COVID -19 associated pneumonia.

Aug 31, 2020

We sought to evaluate the effect of Tocilizumab (TCB), a recombinant humanized monoclonal antibody against soluble interleukin-6 receptors, in patients hospitalized for coronavirus disease 2019 (COVID...

Rate of anastomotic leak following right hemicolectomy by general surgical trainees.

Aug 31, 2020

Performing a right hemicolectomy (RH) is a core technical competency for general surgical trainees. There is a concern that anastomotic leaks occur more frequently when patients are operated on by tra...

Admission IL-32 Concentration Predicts Severity and Mortality of Severe Community-Acquired Pneumonia Independently of Etiology.

Aug 31, 2020

Severe community-acquired pneumonia (SCAP) is a critical disorder with high morbidity and mortality, usually manifested as acute respiratory failure and septic shock generally caused by exaggerated sy...

Correlation of Mean Platelet Volume with ST Segment Resolution after Thrombolytic Therapy in Patients with ST Elevation Myocardial Infarction.

Aug 31, 2020

Acute occlusive thrombosis of the coronary artery is the principal cause of myocardial infarction where platelets play an important role. Large size platelets, easily measured by mean platelets volume...

[Predictive value of N-terminal B-type natriuretic peptide on outcome of elderly hospitalized non-heart failure patients].

Aug 31, 2020

To investigate the predictive value of N-terminal type B natriuretic peptide(NT-proBNP) on the prognosis of elderly hospitalized patients without heart failure(non-heart failure). Elderly patien...

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