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Critical Care General

Evaluating the Timeliness and Specificity of CD69, CD64 and CD25 as Biomarkers of Sepsis in MICE.

Sep 07, 2020

Sepsis occurs when an infection induces a dysregulated immune response, and is most commonly bacterial in origin. This condition requires rapid treatment for successful patient outcomes. However, the ...

Interferon-gamma increases monocyte PD-L1 but does not diminish T-cell activation.

Sep 07, 2020

Immune dysfunction can occur during sepsis or following major trauma. Decreased monocyte HLA-DR expression and cytokine responses are associated with mortality. Recent studies have shown that adaptive...

Quantifying the expense of deferring surgical stabilization of rib fractures: operative management of rib fractures is associated with significantly lower charges.

Sep 07, 2020

Surgical stabilization of rib fractures (SSRF) remains a relatively controversial operation, which is often deferred due to concern about expense. The objective of this study was to determine the char...

GAS5 which is regulated by Lhx8 promotes the recovery of learning and memory in rats with cholinergic nerve injury.

Sep 07, 2020

Damage to the cholinergic system in central nervous system injuries such as traumatic brain injury (TBI) and neurodegenerative diseases leads to impaired learning and cognition. Neural stem cells (NSC...

Persistent Pain, Physical Dysfunction and Decreased Quality of Life after Combat Extremity Vascular Trauma.

Sep 07, 2020

Combat-related extremity vascular injuries (EVI) have long-lasting impact on Iraq/Afghanistan Veterans. The purpose of this study is to describe long-term functional outcomes in Veterans with EVI usin...

Adaptive immune disorders in hypertension and heart failure: focusing on T-cell subset activation and clinical implications.

Sep 07, 2020

: Hypertension is a growing health concern worldwide. Established hypertension is a causative factor of heart failure, which is characterized by increased vascular resistance and intractable uncontrol...

Considerations for long-term dialysis access in patients with left ventricular assist devices.

Sep 07, 2020

Renal dysfunction, requiring renal replacement therapy (RRT) is commonly encountered in patients with left ventricular assist devices (LVAD). Continuous flow LVAD (CFLVAD) is the most widely used devi...

Uric Acid Is a Biomarker of Oxidative Stress in the Failing Heart: Lessons Learned from Trials With Allopurinol and SGLT2 Inhibitors.

Sep 07, 2020

Hyperuricemia increases the risk of heart failure, and higher levels of serum uric acid are seen in patients who have worse ventricular function, functional capacity and prognosis. Heart failure is al...

Inpatient Palliative Care Use in Patients With Pulmonary Arterial Hypertension: Temporal Trends, Predictors, and Outcomes.

Sep 07, 2020

Pulmonary arterial hypertension (PAH) is a progressive disease associated with significant morbidity and mortality. Despite the negative impact of PAH on quality of life and survival, data on use of s...

Angiotensin II Infusion for Shock: A Multicenter Study of Post-Marketing Use.

Sep 07, 2020

Vasodilatory shock refractory to catecholamine vasopressors and arginine vasopressin is highly morbid and responsible for significant mortality. Synthetic angiotensin II is a potent vasoconstrictor wh...

microRNA-421-3p prevents inflammatory response in cerebral ischemia/reperfusion injury through targeting m6A Reader YTHDF1 to inhibit p65 mRNA translation.

Sep 07, 2020

Ischemic stroke is one of the leading causes of death globally, and inflammation is considered as a vital contributor to the pathophysiology of ischemic stroke. Recently, microRNA-421-3p-derived macro...

Effects of tamoxifen and aromatase inhibitors on the risk of acute coronary syndrome in elderly breast cancer patients: An analysis of nationwide data.

Sep 07, 2020

Aromatase inhibitors (AIs) are the preferred endocrine treatment for postmenopausal hormonal receptor-positive breast cancer. However, there is controversy on the long-term cardiovascular and cerebrov...

Spinal neurovascular complications with anterior thoracolumbar spine surgery: a systematic review and review of thoracolumbar vascular anatomy.

Sep 03, 2020

Spinal cord infarction due to interruption of the spinal vascular supply during anterior thoracolumbar surgery is a rare but devastating complication. Here, the authors sought to summarize the data on...

The Value of Thromboelastography in the Diagnosis of Sepsis-Induced Coagulopathy.

Sep 03, 2020

Thromboelastography (TEG) is regularly used for monitoring abnormalities of the coagulation system in patients with sepsis. However, it is unclear whether TEG parameters are associated with sepsis-ind...

Hydrocortisone mitigates ICU-AW by fine-tuning of muscle atrophic and hypertrophic signaling pathways in a sepsis model with limb immobilization.

Sep 03, 2020

Intensive care unit-acquired weakness (ICU-AW) is a complex spectrum of disability that delays recovery of critically ill-immobilized patients with sepsis. Much discrepancy remain on the use of cortic...

COVID-19 and cardiovascular consequences: Is the endothelial dysfunction the hardest challenge?

Sep 03, 2020

A Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) has become a pandemic disease named Coronavirus Disease-19 (COVID-19) of epochal dimension. The clinical spectrum of COVID-19 is wide, ra...

Coronavirus Disease 2019 (COVID-19) diagnostic technologies: A country-based retrospective analysis of screening and containment procedures during the first wave of the pandemic.

Sep 03, 2020

Since first report of a novel coronavirus in December of 2019, the Coronavirus Disease 2019 (COVID-19) pandemic has crippled healthcare systems around the world. While many initial screening protocols...

Mini-open lateral retropleural/retroperitoneal approaches for thoracic and thoracolumbar junction anterior column pathologies.

Sep 03, 2020

Advancements in less invasive lateral retropleural/retroperitoneal approaches aim to address the limitation of posterolateral approaches and avoid complications associated with anterior open thoracoto...

1-Month Results From a Prospective Experience on CAS Using CGuard Stent System: The IRONGUARD 2 Study.

Sep 03, 2020

The study sought to evaluate 30-day safety and efficacy of dual-layer mesh-covered carotid stent systems for carotid artery stenting (CAS) in the clinical practice.When compared with carotid endartere...

Endarterectomy with "systematized" resection anastomosis of carotid bulb, about 240 cases.

Sep 03, 2020

Carotid endarterectomy has traditionally been the strategy for the surgical management of carotid stenosis. Alongside the usual techniques, this study presents another technique: endarterectomy with s...

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