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Critical Care General

Carotid Artery Angioplasty and Stenting for Carotid Stenosis: A Single-Center Experience From Saudi Arabia.

Sep 10, 2020

Atherosclerotic stenosis of the extracranial carotid artery accounts for approximately 20% of all strokes. Both carotid artery endarterectomy and carotid artery angioplasty with stenting (CAAS) are re...

Effectiveness of Polypill for Prevention of Cardiovascular Disease (PolyPars): Protocol of a Randomized Controlled Trial.

Sep 10, 2020

Cardiovascular diseases (CVDs) are the leading cause of death in Iran. A fixed-dose combination therapy (polypill) was proposed as a cost-effective strategy for CVD prevention, especially in lower-res...

Advances in Neonatal Infections.

Sep 10, 2020

Despite continued advances and developments in neonatal medicine, neonatal sepsis is the third leading cause of neonatal mortality and a major public health problem, especially in developing countries...

Do Neonatal Infections Require a Positive Blood Culture?

Sep 10, 2020

Neonatal sepsis is a major cause of worldwide morbidity and mortality. Blood cultures are considered the gold standard for diagnosis, but results are often delayed for 24 to 48 hours, and sensitivit...

The Spanish National Network "Grupo Castrillo": 22 Years of Nationwide Neonatal Infection Surveillance.

Sep 10, 2020

 This study aimed to describe the epidemiology of vertically transmitted sepsis (VS) and nosocomial sepsis (NOS) in very low birth weight (VLBW) neonates (birth weight ≤ 1,500 g) over the pa...

Making a Difference: Affective Distress Explains Discrepancy Between Objective and Subjective Cognitive Functioning After Mild Traumatic Brain Injury.

Sep 10, 2020

To assess the relationship between subjective cognitive symptoms and objective cognitive test scores in patients after concussion. We additionally examined factors associated with subjective and objec...

A practical method for dealing with missing Glasgow Coma Scale verbal component scores.

Sep 10, 2020

The Glasgow Coma Scale (GCS) is used for the assessment of impaired consciousness; however, it is not always possible to test each component, most commonly the verbal component. This affects the deriv...

GLP-1 receptor agonist liraglutide protects cardiomyocytes from IL-1β-induced metabolic disturbance and mitochondrial dysfunction.

Sep 10, 2020

Cardiac inflammation plays a critical role in the development of heart failure. Inflammation-induced oxidative stress contributes to aberrant cardiac metabolism and mitochondrial function. GLP-1 recep...

G6PD, bond by miR-24, regulates mitochondrial dysfunction and oxidative stress in phenylephrine-induced hypertrophic cardiomyocytes.

Sep 10, 2020

Pathological cardiac hypertrophy (CH) is one of the main risk factors for heart failure and cardiac death. Mitochondrial dysfunction and oxidative stress often occur in hypertrophic cardiomyocytes. It...

A simple novel approach for detecting blood-brain barrier permeability using GPCR internalization.

Sep 10, 2020

Impairment of blood-brain barrier (BBB) is involved in numerous neurological diseases from developmental to aging stages. Reliable imaging of increased BBB permeability is therefore crucial for basic ...

Cardioversion Safety - Are We Doing Enough?

Sep 10, 2020

There is a considerable periprocedural risk of thromboembolic events in atrial fibrillation patients undergoing cardioversion, and treatment with anticoagulants is therefore a hallmark of cardioversio...

Calcinosis is associated with ischemic manifestations and increased disability in patients with systemic sclerosis.

Sep 10, 2020

Calcinosis is a debilitating complication of systemic sclerosis (SSc) with no effective treatments. We sought to identify clinical correlations and to characterize complications and disability associa...

NMDA receptors sustain but do not initiate neuronal depolarization in spreading depolarization.

Sep 07, 2020

Spreading depolarization (SD) represents a neurological process characterized by a massive, self-sustaining wave of brain cell depolarization. Understanding its mechanism is important for treating isc...

Evaluation of the Initiation Timing of Hydrocortisone in Adult Patients With Septic Shock.

Sep 07, 2020

Clinical studies evaluating the use of hydrocortisone in patients with septic shock are heterogeneous in design with conflicting results. The appropriate time in which to initiate hydrocortisone after...

Effects of dietary fern (Adiantum capillus-veneris) leaves powder on serum and mucus antioxidant defence, immunological responses, antimicrobial activity and growth performance of common carp (Cyprinus carpio) juveniles.

Sep 07, 2020

A 56-day research was performed to examine the influence of graded levels (0 (control), 0.5, 1 and 2%) of Fern (Adiantum capillus-veneris) leaves powder (FLP) in diet on immune competence and growth o...

Rectal screening displays high negative predictive value for bloodstream infections with (ESBL-producing) gram negative bacteria in neonates with suspected sepsis in a low-resource setting neonatal care unit.

Sep 07, 2020

We analyzed the concordance of rectal swab isolates and blood culture for gram negative bacteria (GNB) isolates in neonates with suspicion of neonatal sepsis admitted to a neonatal care unit in Haiti....

Phillyrin (KD-1) exerts anti-viral and anti-inflammatory activities against novel coronavirus (SARS-CoV-2) and human coronavirus 229E (HCoV-229E) by suppressing the nuclear factor kappa B (NF-κB) signaling pathway.

Sep 07, 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has extensively and rapidly spread in the world, causing an outbreak of acute infectious pneumonia. However, no specific antiviral drugs or...

Clinical significance of high on-treatment platelet reactivity in patients with prolonged clopidogrel therapy.

Sep 07, 2020

Prolonged dual antiplatelet therapy (DAPT) with aspirin and clopidogrel beyond 1 year has shown to reduce ischemic events at the expense of increased bleeding; however, limited data are available on t...

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition.

Sep 07, 2020

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious respiratory virus that can lead to venous/arterial thrombosis, stroke, renal failure, myocardial infarction, thrombo...

Maternal and neonatal outcomes in COVID-19 infected pregnancies: a prospective cohort study.

Sep 07, 2020

Despite the large number of pregnant women with the coronavirus disease 2019 (COVID-19), there is not enough analytical study to compare maternal and fetal consequences of COVID-19 infected with non-i...

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