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Critical Care General

Protective effects of nebivolol on ovarian ischemia-reperfusion injury in rat.

Sep 24, 2020

Ovarian torsion is a common gynecological emergency of reproductive ages, occurring at rates of 2.7-7.4%. This study aimed to evaluate the antioxidant effects of Nebivolol (NEB) and histopathological ...

Berberine reduces gut-vascular barrier permeability via modulation of ApoM/S1P pathway in a model of polymicrobial sepsis.

Sep 24, 2020

The hyperpermeability of gut-vascular barrier (GVB) plays a role in gut-derived sepsis. The goal of this study was to evaluate if berberine might improve hepatic apolipoprotein M (ApoM) generation and...

In-house method for direct bacterial identification in positive blood culture broths using microfiltration, bead beating, and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Sep 24, 2020

Rapid identification of bacterial pathogens facilitates earlier optimization of antibiotic treatment and reduces morbidity and mortality in sepsis patients. The aim of this research was to design an i...

Body composition on low dose chest CT is a significant predictor of poor clinical outcome in COVID-19 disease - A multicenter feasibility study.

Sep 24, 2020

Low-dose computed tomography (LDCT) of the chest is a recommended diagnostic tool in early stage of COVID-19 pneumonia. High age, several comorbidities as well as poor physical fitness can negatively ...

Subtotal functional sialoadenectomy vs four-duct ligation for the treatment of drooling in neurologically impaired children: long-term follow-up.

Sep 24, 2020

The best surgical option to treat drooling in neurodisabilitiesis still under debate. The aim of this study is to describe the technique of subtotal functional sialoadenectomy (SFS) (i.e. four-duct li...

Cardiovascular disease risk stratification by the Framigham score is markedly improved by ambulatory compared with office blood pressure.

Sep 24, 2020

Ambulatory blood pressure (BP) better predicts cardiovascular disease (CVD) outcomes than office BP measurements (OBPM). Nonetheless, current CVD risk stratification models continue to rely on exclusi...

STROKE-CARD care to prevent cardiovascular events and improve quality of life after acute ischaemic stroke or TIA: A randomised clinical trial.

Sep 24, 2020

Patients with ischaemic stroke or transient ischaemic attack (TIA) are at high risk of recurrent stroke and other cardiovascular diseases and commonly suffer from reduced quality of life. We aimed to ...

Validity of presepsin for the diagnosis and prognosis of sepsis in elderly patients admitted to the intensive care unit.

Sep 24, 2020

Preliminary reports suggested that presepsin was a powerful biomarker for sepsis in a general population. However, presepsin levels change with age. This study aimed to investigate the diagnostic and ...

Spectral clustering of risk score trajectories stratifies sepsis patients by clinical outcome and interventions received.

Sep 24, 2020

Sepsis is not a monolithic disease, but a loose collection of symptoms with diverse outcomes. Thus, stratification and subtyping of sepsis patients is of great importance. We examine the temporal evol...

The use of 4-Hexylresorcinol as antibiotic adjuvant.

Sep 24, 2020

Ever decreasing efficiency of antibiotic treatment due to growing antibiotic resistance of pathogenic bacteria is a critical issue in clinical practice. The two generally accepted major approaches to ...

Men's gendered experiences of rehabilitation and recovery following traumatic brain injury: A reflexive thematic analysis.

Sep 24, 2020

Research shows that gender influences men's health-related beliefs and behaviours - including those within the context of traumatic brain injury (TBI) - making it a factor that should be considered wh...

Epidemiology, Prehospital Characteristics and Outcomes of severe Traumatic Brain Injury in the Netherlands: The BRAIN-PROTECT study.

Sep 24, 2020

A thorough understanding of the epidemiology, patient characteristics, trauma mechanisms, and current outcomes among patients with severe traumatic brain injury (TBI) is important as it may inform pot...

Slowed driving reaction time following concussion symptom resolution.

Sep 24, 2020

Concussed patients have impaired reaction time (RT) and cognition following injury that may linger and impair driving performance. Limited research has used direct methods to assess driving-RT post-co...

COVID-19 hits a trial: Arguments against hastily deviating from the plan.

Sep 24, 2020

The COVID-19 pandemic has substantially impacted the conduct of clinical trials. While initially preparing for a period of time, where it would likely be impossible to supervise trials in the usual wa...

Congestive heart failure treated with peritoneal dialysis or hemodialysis: typical patient profile and outcomes in real-world setting.

Sep 24, 2020

Peritoneal dialysis (PD) is increasingly used for the long-term management of hypervolemic refractory congestive heart failure (CHF) patients, in particular when complicated by renal insufficiency. Wh...

"A National Survey of Burnout and Depression Among Fellows Training in Pulmonary and Critical Care Medicine: A Special Report by the APCCMPD.

Sep 24, 2020

The prevalence of burnout and depressive symptoms is high among physician trainees.What is the burden of burnout and depressive symptoms among fellows training in pulmonary and critical care medicine ...

Transient ischemic attack without self-Awareness of symptoms witnessed by bystanders: analysis of the PROMISE-TIA registry.

Sep 24, 2020

Transient ischemic attack (TIA) can occur without self-awareness of symptoms. We aimed to investigate characteristics of patients with tissue-based diagnosis of TIA but having no self-awareness of the...

Stroke Units could be a valid alternative to Intensive Care Units for low-grade aneurysmal subarachnoid haemorrhage patients.

Sep 24, 2020

According to current guidelines, aneurysmal subarachnoid haemorrhage (aSAH) patients are mostly managed in intensive care units (ICU) regardless of baseline severity. We assessed the prognostic and ec...

Circadian influence on the microbiome improves heart failure outcomes.

Sep 24, 2020

Myocardial infarction (MI) leading to heart failure (HF) is a major cause of death worldwide. Previous studies revealed that the circadian system markedly impacts cardiac repair post-MI, and that ligh...

Acute abdomen in adult revealing unusual complicated epiploic appendagitis: A case report.

Sep 21, 2020

Epiploic appendagitis is a torsion of fatty appendages of ligamentum trees (1), it's a rare cause of abdominal pain that usually manifests by right or left iliac fossa pain, reminding of appendicitis,...

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