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Critical Care General

Caveolin-1 derived from brain microvascular endothelial cells inhibits neuronal differentiation of neural stem/progenitor cells in vivo and in vitro.

Sep 28, 2020

Caveolin-1 (Cav-1) is an important modulator for adult neurogenesis in post stroke brain repair but its underlying mechanisms are largely unknown. In the present study, we report that endothelial Cav-...

Cerebellar necrosectomy instead of suboccipital decompression: a suitable alternative in patients with space-occupying cerebellar infarction.

Sep 28, 2020

- Space-occupying cerebellar ischemic strokes (SOCS) often lead to neurological deterioration and require surgical intervention to release pressure from the posterior fossa. Current guidelines recomme...

Mechanical thrombectomy in acute ischemic stroke patients with left ventricular assist device.

Sep 28, 2020

As the number of patients with left ventricular assist device (LVAD) implantation has been increasing, treatment of LVAD-related ischemic stroke is becoming a critical issue. We sought to clarify the ...

Trends, patterns and cause-specific neonatal mortality in Tanzania: a hospital-based retrospective survey.

Sep 28, 2020

Globally, large numbers of children die shortly after birth and many of them within the first 4 wk of life. This study aimed to determine the trends, patterns and causes of neonatal mortality in hospi...

TRAF6-mediated ubiquitination of MST1/STK4 attenuates the TLR4-NF-κB signaling pathway in macrophages.

Sep 28, 2020

Pattern-recognition receptors including Toll-like receptors (TLRs) recognize invading pathogens and trigger an immune response in mammals. Here we show that mammalian ste20-like kinase 1/serine/threon...

Procedural bleeding risk, rather than conventional coagulation tests, predicts procedure related bleeding in cirrhosis.

Sep 28, 2020

Standard coagulation parameters are used to guide prophylactic blood product transfusion prior to invasive procedures in cirrhotic patients despite limited high-quality evidence.We aimed to describe c...

A randomized phase-2 trial of pomalidomide in subjects failing prior therapy of chronic graft-versus-host disease.

Sep 28, 2020

Steroid-refractory chronic graft-versus-host disease (cGvHD) is a therapeutic challenge. Sclerotic skin manifestations are especially difficult to treat. We conducted a randomized phase-2 clinical tri...

Syncope at SARS-CoV-2 onset.

Sep 28, 2020

We describe clinical and laboratory findings in 35 patients tested positive for SARS-CoV-2 by reverse transcriptase-polymerase chain reaction on nasopharyngeal swab experiencing one or multiple syncop...

Venous thromboembolism and bleeding in critically ill COVID-19 patients treated with higher than standard low molecular weight heparin doses and aspirin: A call to action.

Sep 28, 2020

Critically ill COVID-19 patients have a clear pattern of inflammation and hypercoagulable state. The main aim of the study was to evaluate the outcome of severe COVID-19 patients basing on prothrombot...

Isolated Flailed P3 Scallop of the Mitral Valve Leaflet in the Setting of Newly Diagnosed Heart Failure With Preserved Ejection Fraction.

Sep 28, 2020

Mitral valve prolapse (MVP) is characterized by typical fibromyxomatous changes in the mitral leaflet tissue with superior displacement of one or both leaflets into the left atrium. An echocardiogram ...

Post-infarct morphine treatment reduces apoptosis and myofibroblast density in a rat model of cardiac ischemia-reperfusion.

Sep 28, 2020

Following myocardial ischemia, the cardiac tissue undergoes both, physiological and pathological changes to compensate the initial loss of function. Long-term continuous adjustments often take a drast...

The Potential Role of Heparin in Patients With COVID-19: Beyond the Anticoagulant Effect. A Review.

Sep 28, 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is responsible of variable clinical manifestations, ranging from no symptoms to severe pneumonia with acute respiratory distress ...

Acute myopericarditis caused by serovar Enteritidis: a case report.

Sep 28, 2020

Acute myopericarditis can be caused by a myriad of infectious and non-infectious aetiologies, however, it is often considered to be due to self-limiting viral infection. spp. myopericarditis is rare ...

aortic prosthetic valve endocarditis.

Sep 28, 2020

Invasive infections due to spp. (a Gram-positive coryneform) are extremely rare. Only a few cases of bloodstream infections and endocarditis have been described, as bacteraemia due to coryneforms is ...

Adverse Childhood Experience, Genes, and PTSD Risk in Soldiers: A Methylation Study.

Sep 28, 2020

Epigenetics can serve as a marker of susceptibility to many known psychiatric diseases. DNA methylation patterns of multiple genes have been studied in both civilian populations and military personnel...

"Spirituality is everybody's business": an exploration of the impact of spiritual care training upon the perceptions and practice of rehabilitation professionals.

Sep 28, 2020

This study explored the impact of a brief spiritual care training program upon the perceptions and self-reported practice of rehabilitation professionals working in traumatic injury.A qualitative stud...

Spinal cord injury in the United States Army Special Forces.

Sep 28, 2020

Spinal cord injury (SCI) is an area of key interest in military medicine but has not been studied among the US Army Special Forces (SF), the most elite group of US soldiers. SF soldiers make up a disp...

Palliative combined cutting and high-pressure balloon valvuloplasty in six dogs with severe, symptomatic subaortic stenosis.

Sep 28, 2020

Severe subaortic stenosis (SAS) is a congenital heart defect in dogs that often results in clinical signs and reduced survival. The objective of this study was to describe characteristics of dogs with...

Efficacy and safety of sacubitril-valsartan in heart failure: a meta-analysis of randomized controlled trials.

Sep 28, 2020

Sacubitril-valsartan has been shown to have superior effects over angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in patients with heart failure (HF) and hypertension. The e...

NT-proBNP as predictor factor of cardiotoxicity during trastuzumab treatment in breast cancer patients.

Sep 28, 2020

Trastuzumab is a drug used in HER2-positive breast cancer that increases patient survival. Due to cardiotoxicity is the most important side effect of trastuzumab treatment, cardiac monitoring should b...

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