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Critical Care General

Immuno-suppressive hydrogels enhance allogeneic MSC survival after transplantation in the injured brain.

Oct 12, 2020

Traumatic brain injury (TBI) triggers multiple biochemical and cellular processes that exacerbate brain tissue damage through a secondary injury. Therapies that prevent or limit the evolution of secon...

Evaluating Multiple Domains of Health in High School Athletes With Sport-Related Concussion.

Oct 12, 2020

Concussions are shown to hinder multiple health dimensions, including health-related quality of life (HRQOL), suggesting a need for a whole-person approach to assessment and treatment. Patient-reporte...

sST2 and Diuretic Efficiency in Acute Heart Failure and Concomitant Renal Dysfunction.

Oct 12, 2020

Identifying patients at risk of poor diuretic response in acute heart failure (AHF) is critical to make prompt adjustments in therapy. The objective of this study was to investigate whether the circul...

Plasma Volume Status and its Association with In-Hospital and Post-Discharge Outcomes in Decompensated Heart Failure.

Oct 12, 2020

Prior analyses suggest an association between formula-based plasma volume (PV) estimates and outcomes in heart failure (HF). We assessed the association between estimated PV-status by the Duarte-ePV a...

VENTILATION DISPERSION INDEX AS AN OBJECTIVE EVALUATION TOOL OF EXERCISE OSCILLATORY VENTILATION IN PATIENTS WITH HEART FAILURE.

Oct 12, 2020

Exercise oscillatory ventilation (EOV) is related to worse prognosis in patients with heart failure (HF). However, its determination is subjective and there is no standard measure to identify it. The ...

Acute injection of a DHA triglyceride emulsion after hypoxic-ischemic brain injury in mice increases both DHA and EPA levels in blood and brain.

Oct 12, 2020

We recently reported that acute injection of docosahexaenoic acid (DHA) triglyceride emulsions (tri-DHA) conferred neuroprotection after hypoxic-ischemic (HI) injury in a neonatal mouse stroke model. ...

Associations between short-term exposure to PM and stroke incidence and mortality in China: A case-crossover study and estimation of the burden.

Oct 08, 2020

Stroke and fine particulate matter (PM) are two important public health concerns worldwide. Although numerous studies have reported the associations between PM and stroke, scientific evidence in China...

Covid-19 and kidney injury: Pathophysiology and molecular mechanisms.

Oct 08, 2020

The novel coronavirus (SARS-CoV-2) has turned into a life-threatening pandemic disease (Covid-19). About 5% of patients with Covid-19 have severe symptoms including septic shock, acute respiratory dis...

Novel anti-tubercular and antibacterial based benzosuberone-thiazole moieties: Synthesis, molecular docking analysis, DNA gyrase supercoiling and ATPase activity.

Oct 08, 2020

Herein, molecular hybridization strategy was utilized in the design of new benzosuberone-thiazole derivatives. The structures of the synthesized hybrids were determined on the basis of elemental and s...

SARS-CoV-2 infections in cancer outpatients-Most infected patients are asymptomatic carriers without impact on chemotherapy.

Oct 08, 2020

Oncologic patients are regarded as the population most at risk of developing a severe course of COVID-19 due to the fact that malignant diseases and chemotherapy often weaken the immune system. In the...

Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis.

Oct 08, 2020

Dyslipidaemia has a prominent role in the onset of notorious atherosclerosis, a disease of medium to large arteries. Atherosclerosis is the prime root of cardiovascular events contributing to the most...

Predictive value of sirtuins in acute myocardial infarction - Bridging the bench to the clinical practice.

Oct 08, 2020

Acute myocardial infarction (AMI) is a non-transmissible condition with high prevalence, morbidity, and mortality. Different strategies for the management of AMI are employed worldwide, but its early ...

Microcirculatory, Endothelial and Inflammatory Responses in Critically Ill Patients with COVID-19 are Distinct from those Seen in Septic Shock: A Case Control Study.

Oct 08, 2020

Critically ill patients with COVID-19 infection frequently exhibit a hyperinflammatory response and develop organ failures, however the underlying mechanisms are unclear. We investigated the microcirc...

The SPaCE diagnostic: a pilot study to test the accuracy of a novel point of care sensor for point of care detection of burn wound infection.

Oct 08, 2020

Wound infection in burn patients is common and impacts outcomes. There is no objective method to diagnose infection at point of care (PoC). Early diagnosis prevents progression to sepsis. Diagnostic s...

Targeting acute kidney injury in COVID-19.

Oct 08, 2020

As of 15 August 2020, Coronavirus disease 2019 (COVID-19) has been reported in >21 million people world-wide and is responsible for more than 750,000 deaths. The occurrence of acute kidney injury (...

Personalized Web-Based Cognitive Rehabilitation Treatments for Patients with Traumatic Brain Injury: Cluster Analysis.

Oct 08, 2020

Traumatic brain injury (TBI) is a leading cause of disability worldwide. TBI is a highly heterogeneous disease, which makes it complex for effective therapeutic interventions. Cluster analysis has bee...

Seeded laser-induced cavitation for studying high-strain-rate irreversible deformation of soft materials.

Oct 08, 2020

Characterizing the high-strain-rate and high-strain mechanics of soft materials is critical to understanding the complex behavior of polymers and various dynamic injury mechanisms, including traumatic...

The Brain Injury Functional Outcome Measure (BI-FOM): A single instrument capturing the range of recovery in moderate-severe traumatic brain injury.

Oct 08, 2020

To develop a measure of global functioning after moderate-severe TBI with similar measurement precision but a longer measurement range than the FIM.Phase 1: Retrospective analysis of 5 data sets conta...

Interatrial Block Predicts Atrial Fibrillation and Total Mortality in Patients with Cardiac Resynchronization Therapy.

Oct 08, 2020

Interatrial block (IAB) and abnormal P-wave terminal force in lead V1 (PTFV1) are electrocardiographic (ECG) abnormalities that have been shown to be associated with new-onset atrial fibrillation (AF)...

Usefulness of Peritoneal Ultrafiltration in Patients with Diuretic Resistant Heart Failure without End-Stage Renal Disease.

Oct 08, 2020

This study aimed to explore the role of peritoneal ultrafiltration (UF) in cardiorenal syndrome (CRS) patients for fluid and metabolic control.Peritoneal UF is safely and efficiently used for the mana...

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