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Critical Care General

ACUTE UNLOADING EFFECTS OF SILDENAFIL ENHANCE RIGHT VENTRICULAR-PULMONARY ARTERY COUPLING IN HEART FAILURE.

Nov 26, 2020

Phosphodiesterase-5A inhibitors (PDE5i) are sometimes used in patients with advanced HFrEF prior to heart transplant or LVAD to reduce RV afterload and mitigate the risk of right HF. Conflicting evide...

Increased risk of ischemic heart disease and diabetes in inflammatory bowel disease.

Nov 26, 2020

 Previous studies showed inconsistent results regarding associations between inflammatory bowel disease (IBD) and risk of ischemic heart disease (IHD) and diabetes. The present study aimed to make a...

Therapeutic Potential of Nutraceuticals to Protect Brain after Stroke.

Nov 23, 2020

Stroke leads to significant neuronal death and long-term neurological disability due to synergistic pathogenic mechanisms. Stroke induces a change in eating habits and in many cases, leads to undernut...

Effect of acute and subchronic administration of (R)-WIN55,212-2 induced neuroprotection and anti inflammatory actions in rat retina: CB1 and CB2 receptor involvement.

Nov 23, 2020

Cannabinoids have been shown to protect the retina from ischemic/excitotoxic insults. The aim of the present study was to investigate the neuroprotective and anti-inflammatory properties of the synthe...

Is obesity associated with short-term revision after total knee arthroplasty? An analysis of 121,819 primary procedures from the Dutch Arthroplasty Register.

Nov 23, 2020

The prevalence of obesity is increasing. The association with knee osteoarthritis is well documented, resulting in the population requesting total knee arthroplasty (TKA) for invalidating symptoms to ...

High-performance low field MRI enables visualization of persistent pulmonary damage after COVID-19.

Nov 23, 2020

The outbreak of coronavirus disease 2019 (COVID-19) with the origin of the spread assumed to be located in Wuhan, China, began in December 2019, and is continuing until now. With the COVID-19 pandemic...

Ambient PM and its chemical constituents on lifetime-ever pneumonia in Chinese children: A multi-center study.

Nov 23, 2020

The long-term effects of ambient PM and chemical constituents on childhood pneumonia were still unknown. A cross-sectional study was conducted in 30,315 children in the China Children, Homes, Health (...

Prevalence, incidence, and outcomes across cardiovascular diseases in homeless individuals using national linked electronic health records.

Nov 23, 2020

The risk and burden of cardiovascular disease (CVD) are higher in homeless than in housed individuals but population-based analyses are lacking. The aim of this study was to investigate prevalence, in...

C-reactive protein- and clinical symptoms-guided strategy in term neonates with early-onset sepsis reduced antibiotic use and hospital stay: a quality improvement initiative.

Nov 23, 2020

Early-onset sepsis (EOS) is a potentially life-threatening complication of birth. Clinical symptoms are often unspecific and biomarkers have low predictive values for EOS. Therefore, clinical suspicio...

N-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation.

Nov 23, 2020

Bacterial infection triggers a cytokine storm that needs to be resolved to maintain the host's wellbeing. Here, we report that ablation of mA methyltransferase subunit METTL14 in myeloid cells exacerb...

Quantitative susceptibility mapping of the rat brain after traumatic brain injury.

Nov 23, 2020

The primary lesion arising from the initial insult after traumatic brain injury (TBI) triggers a cascade of secondary tissue damage, which may also progress to connected brain areas in the chronic pha...

Dentoalveolar Injuries, Bicycling Accidents and Helmet Use in Patients Referred to a Norwegian Trauma Centre: A 12-year Prospective Study.

Nov 23, 2020

Despite its many benefits, bicycling carries the risk of accidents. Although numerous studies have reported the effect of helmet use on traumatic brain injury, it remains unclear if, and to what exten...

The use of inertial measurement units to assess gait and postural control following concussion.

Nov 23, 2020

Impairments in gait and balance function are typical after concussion. There is evidence that these neuromuscular deficits persist past the typical time of symptom resolution. The ability to quantify ...

Zika & Heart: A systematic review: Zika & Heart.

Nov 23, 2020

Zika virus infection affects more than 80 countries in the world, mainly those with a tropical climate. Although the most frequent clinical presentation is characterized by rash, conjunctivitis, myalg...

Worsening Racial Disparities in Patients Undergoing Anatomic and Reverse Total Shoulder Arthroplasty in the United States.

Nov 23, 2020

The most comprehensive healthcare policy changes aimed at reducing racial disparities were implemented in 2011 and continue today. It is unknown if these initiatives have led to a decrease in racial d...

Dexmedetomidine exerts cardioprotective effect through miR-146a-3p targeting IRAK1 and TRAF6 via inhibition of the NF-κB pathway.

Nov 23, 2020

Myocardial ischemia/reperfusion (I/R) injury is a common cause of mortality. Cardiac miR-146a is emerging as a potent regulator of myocardial function. Dexmedetomidine preconditioning provides cardiop...

Strain-Guided Management of Potentially Cardiotoxic Cancer Therapy.

Nov 23, 2020

In patients at risk of cancer therapy-related cardiac dysfunction (CTRCD), initiation of cardio-protective therapy (CPT) is constrained by the low sensitivity of EF for minor changes in LV function. G...

Pneumonia in medical professionals during COVID-19 outbreak in cardiovascular hospital.

Nov 23, 2020

The pandemic of coronavirus associated disease (COVID-19) placed the health care workers at high risk. We investigated clinical and treatment characteristics of infected medical professionals in a car...

Left ventricular circumferential strain and coronary microvascular dysfunction: A report from the Women's Ischemia Syndrome Evaluation Coronary Vascular Dysfunction (WISE-CVD) Project.

Nov 19, 2020

Women with ischemia but no obstructive coronary artery disease (INOCA) often have coronary microvascular dysfunction (CMD). Left ventricular (LV) circumferential strain (CS) is often lower in INOCA co...

Treatment of Cognitive Impairment and the Role of Demographic Factors in Disease Progression: The Final Results of the Russian Observational Program "DIAMANT".

Nov 19, 2020

Chronic cerebral ischemia (CCI) is a form of cerebrovascular disease manifested as a vascular cognitive impairment (VCI). The management of the patients with CCI is determined by a healthy lifestyle a...

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