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Critical Care General

Mechanosensation in traumatic brain injury.

Dec 03, 2020

Traumatic brain injury (TBI) is distinct from other neurological disorders because it is induced by a discrete event that applies extreme mechanical forces to the brain. This review describes how the ...

Local delivery of RhoA siRNA by PgP nanocarrier reduces inflammatory response and improves neuronal cell survival in a rat TBI model.

Dec 03, 2020

Traumatic brain injury (TBI) is a leading cause of death and disability with complex pathophysiology including prolonged neuroinflammation, apoptosis, and glial scar formation. The upregulation of Rho...

Effect of Yugengtongyu Granules in Patients with Stable Coronary Artery Disease on Reducing Adverse Cardiovascular Events: A Double-Blind Controlled Trial.

Dec 03, 2020

To evaluate the effect of Yugengtongyu granules on reducing the incidence of adverse cardiovascular events and improving quality of life (QOL) in patients with stable coronary artery disease (SCAD). ...

Systematic analysis of molecular mechanisms of heart failure through the pathway and network-based approach.

Dec 03, 2020

The molecular networks and pathways involved in heart failure (HF) are still largely unknown. The present study aimed to systematically investigate the genes associated with HF, comprehensively explor...

Transcatheter Mitral Valve Repair in Patients with Heart Failure: A Meta-Analysis.

Dec 03, 2020

Severe secondary mitral regurgitation (MR) is associated with poor prognosis in heart failure patients with left ventricular systolic dysfunction. Few observational and randomized controlled studies d...

The effect of bed-to-nurse ratio on hospital mortality of critically ill children on mechanical ventilation: a nationwide population-based study.

Dec 03, 2020

Despite the high workload of mechanical ventilation, there has been a lack of studies on the association between nurse workforce and mortality in mechanically ventilated patients. We evaluated the ass...

Pre-Stroke Glycemic Variability Estimated by Glycated Albumin Is Associated with Early Neurological Deterioration and Poor Functional Outcome in Prediabetic Patients with Acute Ischemic Stroke.

Dec 03, 2020

Whether glycemic variability prior to stroke increases the risk of stroke outcomes in prediabetic patients presenting with acute ischemic stroke is still unclear. We evaluated whether pre-stroke glyce...

Risk of Ischemic Stroke after an Inpatient Hospitalization for Transient Ischemic Attack in the United States.

Dec 03, 2020

A diagnosis of transient ischemic attack (TIA) must be followed by prompt investigation and rapid initiation of measures to prevent stroke. Prior studies evaluating the risk of stroke after TIA were c...

Estimating Shortages of Continuous Kidney Replacement Therapy During COVID-19

Dec 01, 2020

During the current COVID-19 pandemic, there has been a surge in patients requiring intensive care throughout the United States. “Early in the pandemic, US healthcare systems worked to increase the n...

Assessment of antıbıotıc resıstance of ınfectıous agents ın patıents wıth pneumonıa ın tertıary crıtıcal care unıt and effect on clınıcal outcomes.

Nov 30, 2020

The aim of this study was to determine the prevalence of the causative agents of multi-drug resistant bacteria in pneumonia and also evaluate their mortality rates in the intensive care unit (ICU).Thi...

National Current Care Guidelines for paediatric lower respiratory tract infections reduced the use of chest radiographs but local variations were observed.

Nov 30, 2020

Our aim was to evaluate the impact of the 2014 Finnish Current Care Guidelines for paediatric lower respiratory tract infections (LRTIs), particularly on taking of chest radiographs.This study used of...

RAC1 nitration at Y IS involved in the endothelial barrier disruption associated with lipopolysaccharide-mediated acute lung injury.

Nov 30, 2020

Acute lung injury (ALI), a devastating illness induced by systemic inflammation e.g., sepsis or local lung inflammation e.g., COVID-19 mediated severe pneumonia, has an unacceptably high mortality and...

The management of non-culprit coronary lesions in patients with acute coronary syndrome.

Nov 30, 2020

About 50% of patients diagnosed with ST-segment elevation myocardial infarction have multivessel disease on coronary angiography. Recent evidence has shown that a staged percutaneous coronary interven...

Can carotid artery calcifications on dental radiographs predict adverse vascular events? A systematic review.

Nov 30, 2020

To investigate the predictive value of carotid artery calcifications (CACs) seen on dental imaging for future adverse events related to cerebrovascular and cardiovascular diseases.Electronic databases...

Optimal Empiric Treatment for Infections in Short-Stay ICU Patients During Continuous Renal Replacement Therapy: Results from a Population Pharmacokinetic/Pharmacodynamic Analysis.

Nov 30, 2020

There is a paucity of published data to evaluate the efficacy and safety of imipenem (IPM) and piperacillin-tazobactam (PT) dosing regimens in the treatment of septic patients acquiring continuous ren...

Primarily treated patients versus referred patients in the treatment of native septic arthritis of digits: a retrospective comparative study.

Nov 30, 2020

Septic arthritis of digits needs urgent treatment. When treatments delayed or insufficient, patients may be referred to the upper-level hospital due to uncontrolled infection. We reviewed the treatmen...

Gene expression signatures identify paediatric patients with multiple organ dysfunction who require advanced life support in the intensive care unit.

Nov 30, 2020

Multiple organ dysfunction syndrome (MODS) occurs in the setting of a variety of pathologies including infection and trauma. Some patients decompensate and require Veno-Arterial extra corporeal membra...

Position Paper on Post-Traumatic Headache: The Relationship Between Head Trauma, Stress Disorder, and Migraine.

Nov 30, 2020

Traumatic brain injury (mTBI) is a major public health concern, with mild TBI (mTBI) constituting the vast majority of the injuries. Post-traumatic headache (PTH) is one of the most frequent symptoms ...

Effects of Fibrinogen Synthesis Inhibition on Vascular Cognitive Impairment during Traumatic Brain Injury in Mice.

Nov 30, 2020

Traumatic brain injury (TBI) is associated with increased blood content of fibrinogen (Fg), called hyperfibrinogenemia (HFg), which results in enhanced cerebrovascular permeability and leads to short-...

Ion Channels and Transporters in Microglial Function in Physiology and Brain Diseases.

Nov 30, 2020

Microglial cells interact with all components of the central nervous system (CNS) and are increasingly recognized to play essential roles during brain development, homeostasis and disease pathologies....

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