Discharge from pediatric intensive care unit after respiratory failure may be associated with long-term impact on neurocognition
1. Patients who were discharged from a pediatric intensive care unit for respiratory failure were...
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chronic-disease
Congenital Zika syndrome is associated with higher risk of death
1. Children with congenital Zika syndrome had a higher risk of death throughout the first 3 years...
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S-1 plus oxaliplatin noninferior to fluorouracil, leucovorin, and oxaliplatin in perioperative chemotherapy for locally advanced gastric cancer: FOCUS trial
1. This phase 3, randomized controlled trial demonstrated that S-1 plus oxaliplatin (SOX) was...
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Peanut oral immunotherapy desensitizes young children with non-anaphylactic peanut allergies
1. Compared to placebo, children who received peanut oral immunotherapy experienced significantly...
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LentiGlobin efficacious for sickle cell disease hemolysis and vaso-occlusion
1. LentiGlobin gene therapy resulted in sustained production of the modified anti-sickling...
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Addition of atezolizumab to capecitabine + bevacizumab is not clinically beneficial in the treatment of refractory metastatic colorectal cancer
1. Atezolizumab plus capecitabine + bevacizumab performed marginally better with regards to...
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Chemotherapy not associated with an increased COVID-19 mortality risk in active cancer patients
1. This prospective cohort study demonstrated that, in adult patients with active cancer and a...
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Three-step support strategy reduces prolonged grief in relatives after death of intensive care unit patients
1. Grief measured at 6 months following the patient’s death was significantly lower in relatives...
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COVID-19 increased mortality disaster in Switzerland, Sweden, and Spain
1. COVID-19 caused the second-largest infection-related mortality disaster in Switzerland, Sweden,...
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Cervical intraepithelial neoplasia grade 3 associated with adverse pregnancy outcomes
1. Compared to population- and sibling-matched cohorts, women previously diagnosed with cervical...
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Increased affective and sleep symptoms reported after late presentation for concussion
1. In this retrospective study, individuals who sought care at a concussion specialty clinic 15-30...
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Traumatic brain injury associated with increased all-cause mortality risk for military veterans
1. This retrospective cohort study found that, in comparison to the total US population, post-9/11...
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Psychological experiment suggests genetic testing may influence neonatologists’ clinical decision-making
1. A randomized, split-block psychological experiment utilizing clinical vignettes provides...
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Trametinib improves progression-free survival among patients with low-grade serous ovarian carcinoma
1. The median progression-free survival for trametinib was significantly greater than that for...
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Venous thromboembolism rates in hospitalized children continue to rise
1. In a large retrospective study, rates of venous thromboembolism (VTE) in pediatric patients...
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Oral HIV preexposure prophylaxis limits willingness to pay for long-acting injectable prophylaxis
1. Compared with generic oral emtricitabine-tenofovir disoproxil fumarate (F/TDF), long-acting...
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Oral HIV preexposure prophylaxis limits willingness to pay for long-acting injectable prophylaxis
1. Compared with generic oral emtricitabine-tenofovir disoproxil fumarate (F/TDF), long-acting...
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Absence of coronary plaque among symptomatic patients with high low-density lipoprotein cholesterol levels associated with low risk of atherosclerotic cardiovascular disease events
1. Among symptomatic patients with high low-density lipoprotein cholesterol levels considered high...
Read MorePsychosocial barriers may hinder expanded buprenorphine access amongst opioid use disorder patients
1. In this study, counselors reported that patients would be more likely to access buprenorphine treatment if they had access to greater social resources, such as housing or internet. 2. Counselors also report that increased screening at intake about psychosocial factors would be helpful. Evidence Rating Level: 3 (Average) One of the current national public […]
Read MoreAllopurinol Does Not Increase Mortality in Patients With Gout & Chronic Kidney Disease
1. In patients with gout and chronic kidney disease, the initiation of allopurinol was not associated with increased mortality. 2. In patients with gout and chronic kidney disease, dose escalation of allopurinol nor achieving target serum urate levels was associated with increased mortality. Evidence Rating Level: 2 (Good) Study Rundown: Serum urate (SU) lowering medications […]
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