OPTION: LAAC Over OAC After Ablation in Patients With AF & Increased Stroke Risk
Ablation plus LAAC resulted in better safety outcomes than ablation plus OAC in patients with AF who underwent ablation and had an increased risk for stroke.
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Author: Teresa Sellinger
Novel Small-Interfering RNA Effectively Reduced Lp(a) in Phase 2
Zerlasiran was associated with deep reductions in Lp(a) levels in patients with elevated Lp(a) levels and risk for atherosclerotic CVD-related events
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TOPSPIN: Comparing Dual Antihypertensive Therapies in a South Asian Population
Three different dual antihypertensive therapies demonstrated safety and effectiveness among patients from India with uncontrolled BP in the TOPSPIN trial.
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KRAKEN: Encouraging Phase 2 Results of Lp(a)-Lowering Muvalaplin
In the KRAKEN study, muvalaplin rapidly reduced Lp(a) in patients with elevated Lp(a) levels and a heightened risk for adverse cardiovascular events.
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VANISH2: Antiarrhythmic Drug Therapy or Catheter Ablation in MI Plus VT?
VANISH2 findings showed that first-line catheter ablation reduced death and serious arrhythmia outcomes in patients with prior MI and ventricular tachycardia.
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XG005 Relieves Knee OA Symptoms in Phase 2b Study
XG005, a non-opioid oral agent, showed strong efficacy and tolerability in relieving knee OA symptoms in a phase 2b trial, offering a promising treatment option.
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ICI Therapy Does Not Increase Mortality Risk in Patients With Pre-Existing Autoimmune Disease
The mortality risk in patients with pre-existing auto-immune disease is not significantly different from those without AIDS, in an immune checkpoint inhibitor study.
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TAPIR: Fully Tapering Off Glucocorticoids May Be a Viable Option for GPA
After patients with granulomatosis with polyangiitis achieve remission, discontinuing glucocorticoids could be a viable option.
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Global Recruitment Associated With Higher Placebo Responses in PsA Trials
A systematic review has found that the globalization of recruitment significantly contributes to the higher placebo rates observed in recent psoriatic arthritis clinical trials.
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Favorable Benefit-Risk Profile of Upadacitinib in Giant Cell Arteritis
In the SELECT-GCA trial, upadacitinib was found to be superior in comparison to a placebo in patients with giant cell arteritis.
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Q&A: Assessing RSV as a Newly Vaccine-Preventable Disease
Fiona P. Havers, MD, MHS, spoke with Physician’s Weekly about managing RSV as a newly vaccine-preventable disease now that multiple vaccines have been approved.
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Model Predicts Stillbirths Using Preeclampsia Screening Data
A new study showed that a first-trimester screening model combining maternal, biophysical, and biochemical markers effectively predicted stillbirths.
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Preeclampsia’s Impact on Maternal & Neonatal Outcomes
Preeclampsia poses significant maternal and neonatal risks, with long-term complications like chronic diseases in mothers and developmental issues in children.
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Protein Loss Predicts EC Prognosis
Loss of vimentin in endometrial cancer biopsies predicted metastases and worse survival, supporting its use in risk stratification and personalized treatment.
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Gaps Identified in EC Clinical Trial Enrollment
Recent study findings indicate Black patients with endometrial cancer are underrepresented in clinical trials despite higher rates of aggressive histologies.
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Identifying Patients With IPAH at Risk for Poor Outcomes
Right atrial volume index and contour changes on imaging predicted adverse outcomes in patients with idiopathic pulmonary arterial hypertension.
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Metabolic Disorders Higher in PAH vs Controls
Patients with pulmonary arterial hypertension had higher rates of metabolic disorders, hypothyroidism, and low bone density than healthy controls.
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Mapping Psychosocial Vulnerabilities to Enhance Outcomes in HIV & Substance Use
Psychosocial profiles identified in patients with HIV who use substances may improve outcomes for both conditions through tailored interventions.
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Murder of a Healthcare CEO: Why Doctors Should Care
The shocking murder of UnitedHealthcare CEO Brian Thompson in NYC highlights the need for nonviolent advocacy to fix a broken healthcare system. Violence solves nothing.
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Expanded Admission Screening Protocol for C. Auris Beneficial
An expanded screening protocol for Candida auris at admission can improve infection control and reduce potential pathogen outbreaks.
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